Invasive aspergillosis in patients with systemic lupus erythematosus: a retrospective study on clinical characteristics and risk factors for mortality

Lupus
M L HungD M Chang

Abstract

Objective The objective of this paper is to analyze the clinical features, outcomes, mortality risk factors, and all-cause mortalities of invasive aspergillosis (IA) in patients with systemic lupus erythematosus (SLE). Methods Medical records were reviewed to identify SLE patients with IA from January 2006 to June 2017, at Taipei Veterans General Hospital, Taiwan. A total of 6714 SLE patients were included. Clinical/laboratory parameters and treatment outcomes were analyzed. Results Four patients (19.0%) had definite and 17 had probable (81.0%) IA. Seven patients (33.3%) survived and 14 died (66.7%). Concurrently, there were 19 pneumonias (90.5%), 17 cases of other infections (81.0%), eight bacteremia (38.1%), nine cytomegalovirus (CMV, 42.7%) and six Candida (28.6%) infections. In all 55 blood cultures, 38 (69.1%) yielded gram-negative bacilli, of which carbapenem-resistant A. baumannii accounted for eight (21.1%); 17 (30.9%) yielded gram-positive cocci, of which methicillin-resistant S. aureus accounted for six (35.3%); and vancomycin-resistant Enterococcus accounted for four (23.5%). Daily steroid dose ≥ 20 mg (hazard ratio (HR) 2.00), recent pulse steroid therapy (HR 2.80), azathioprine (HR 2.00), rituximab (HR 2.00), plasm...Continue Reading

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Citations

Feb 21, 2019·Rapid Communications in Mass Spectrometry : RCM·Kseniia A KravchenkoChristian C Voigt
May 28, 2020·Journal of Medical Microbiology·François DanionFanny Lanternier
Aug 21, 2020·Emerging Infectious Diseases·Ling-Hong ZhouLi-Ping Zhu
Mar 18, 2020·Case Reports in Infectious Diseases·Rochelle HardieYamen Homsi

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Methods Mentioned

BETA
bronchoalveolar lavage
biopsy

Software Mentioned

Statistical Package for Social Sciences ( SPSS )

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