Invasive Breast Carcinoma Arising in a Nipple Adenoma After 15 Years: Report of a Rare Case and Literature Review

Curēus
Muhammad AbdulwaaseyNaila Kayani

Abstract

Nipple adenoma (NA) is a rare benign breast neoplasm that seldom co-exists with breast carcinoma (BC). Majority of these BC are separate from NA, and their origin from NA is an extremely rare event. We herein describe a case of 65-year-old female who had a painless lump for 15 years which increased in size and ulcerated for last six months. Microscopic examination of the wedge biopsy of nipple showed features of NA at superficial aspect and invasive carcinoma from it at the deeper aspect. The patient underwent mastectomy and axillary clearance, which revealed a 4-cm invasive breast carcinoma, no special type with axillary lymph node involvement. The patient received adjuvant chemotherapy, radiotherapy and adjuvant hormonal therapy. The patient is alive and disease-free after 36 months. NA should be carefully evaluated for co-existent BC because it completely changes the treatment plan and prognosis.

References

Feb 7, 2008·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Darlene Da CostaLisa E Esserman
Jun 17, 2014·Oncology Letters·Maurizio DI BonitoGerardo Botti
Jul 22, 2016·Histopathology·Jau-Yu LiauYi-Shuan Sheen
Feb 13, 2018·Archives of Pathology & Laboratory Medicine·Mary Ann SandersSusan C Lester

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Citations

Nov 5, 2021·Virchows Archiv : an International Journal of Pathology·Janina KulkaSigurd F Lax

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Methods Mentioned

BETA
surgical resection
biopsy

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