Invasive endocervical adenocarcinoma: a new pattern-based classification system with important clinical significance

The American Journal of Surgical Pathology
Andres A RomaElvio G Silva

Abstract

A new 3-tier pattern-based system to classify endocervical adenocarcinoma was recently presented. In short, pattern A tumors were characterized by well-demarcated glands frequently forming clusters or groups with relative lobular architecture. Pattern B tumors demonstrated localized destructive invasion defined as desmoplastic stroma surrounding glands with irregular and/or ill-defined borders or incomplete glands and associated tumor cells (individual or small clusters) within the stroma. Tumors with pattern C showed diffusely infiltrative glands with associated extensive desmoplastic response. In total, 352 cases (all FIGO stages) from 12 institutions were identified. Mean patient age was 45 years (range, 20 to 83 y). Forty-nine (13.9%) cases demonstrated lymph nodes (LNs) with metastatic endocervical carcinoma. Using this new system, 73 patients (20.7%) were identified with pattern A tumors (all stage I); none had LN metastases and/or recurrences. Ninety patients (25.6%) were identified with pattern B tumors (all stage I); only 4 (4.4%) had LN metastases; 1 had vaginal recurrence. The 189 (53.7%) remaining patients had pattern C tumors; 45 (23.8%) of them had LN metastases. This new classification system demonstrated 20.7% o...Continue Reading

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Citations

May 14, 2016·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Carlos Parra-HerranBrooke E Howitt
Jun 4, 2016·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Joanne K L RutgersElvio G Silva
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Methods Mentioned

BETA
dissection
hysterectomy
biopsies

Software Mentioned

Excel
SPSS

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