Invasive group A streptococcal disease in Taiwan is not associated with the presence of streptococcal pyrogenic exotoxin genes

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
P R HsuehK T Luh

Abstract

We reviewed the clinical features of 44 patients with invasive group A streptococcal (GAS) disease who were treated at two teaching hospitals in southern Taiwan from 1991 to 1994. Genes encoding streptococcal pyrogenic exotoxin types A (speA), B (speB), C (speC), and F (speF) and serotypes of M1, M6, and M12 were determined by polymerase chain reaction to target specific sequences in the 44 isolates recovered from these patients and in 28 isolates recovered from upper respiratory sites in 28 additional patients during the study period. The protease activity of these isolates was tested by using the casein plate method. Of the 44 patients with invasive diseases, 25 (57%) had no obvious underlying diseases, and 14 (32%) had preexisting neoplastic diseases or had previously used steroids. Twenty-five patients (57%) presented with cellulitis or necrotizing fasciitis, 24 (55%) had bacteremia, and eight (18%) had streptococcal toxic shock syndrome (STSS). Eight patients (18%) died of invasive GAS disease; seven had STSS, and seven had underlying diseases. All eight patients died within 48 hours after hospitalization. The presence of speA, speC, or speF was not implicated in any particular clinical syndrome in patients with invasive G...Continue Reading

Citations

Aug 31, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S RantalaJ Syrjänen
Jan 14, 2004·Journal of Paediatrics and Child Health·A B CengizT Ince
Jun 25, 2003·Antimicrobial Agents and Chemotherapy·Po-Ren HsuehUNKNOWN SMART Program 2001 Data
Sep 8, 2006·Journal of Clinical Microbiology·Katarzyna SzczypaWaleria Hryniewicz
Oct 26, 2007·Journal of Clinical Microbiology·Bogdan Luca-HarariAftab Jasir
Jan 13, 2004·Journal of Clinical Microbiology·Shinnosuke HashikawaMichio Ohta
Mar 22, 2005·Paediatric Drugs·Yu-Yu ChuangTzou-Yien Lin
Nov 12, 2003·Emerging Infectious Diseases·Thomas ProftJohn D Fraser
Feb 12, 2005·Emerging Infectious Diseases·Maria-Graciela Hollm-DelgadoPierre A Pilon
Nov 12, 2013·Trends in Molecular Medicine·Robert J CommonsNigel Curtis
Oct 9, 2002·Molecular Microbiology·Carlos Hidalgo-GrassEmanuel Hanski
Feb 6, 2016·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Takuya HattoriNorihiro Yuasa
Aug 30, 2011·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Yu-Chia Hsieh, Yhu-Chering Huang
Sep 18, 2008·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Chuan Chiang-Ni, Jiunn-Jong Wu
Oct 18, 2015·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Hsien-Meng ChenChih-Yen Chang
Dec 17, 2009·Pathology·Janice C K ChanJanice Y C Lo
Dec 7, 2005·Biochemical and Biophysical Research Communications·Nina TsaoChih-Feng Kuo
Oct 13, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Chih-Feng KuoYee-Shin Lin
May 17, 2005·Microbes and Infection·Mark R DaviesKadaba S Sriprakash

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cellulitis

Cellulitis (erysipelas) is a recurring and debilitating bacterial infection of the skin and underlying tissue. Discover the latest research on cellulitis here.