Invasive Group A Streptococcus Infection among Children, Rural Kenya

Emerging Infectious Diseases
Anna C SealeJames A Berkley

Abstract

To determine the extent of group A Streptococcus (GAS) infections in sub-Saharan Africa and the serotypes that cause disease, we analyzed surveillance data for 64,741 hospital admissions in Kilifi, Kenya, during 1998-2011. We evaluated incidence, clinical presentations, and emm types that cause invasive GAS infection. We detected 370 cases; of the 369 for which we had data, most were skin and soft tissue infections (70%), severe pneumonia (23%), and primary bacteremia (14%). Overall case-fatality risk was 12%. Incidence of invasive GAS infection was 0.6 cases/1,000 live births among neonates, 101/100,000 person-years among children <1 year of age, and 35/100,000 among children <5 years of age. Genome sequencing identified 88 emm types. GAS causes serious disease in children in rural Kenya, especially neonates, and the causative organisms have considerable genotypic diversity. Benefit from the most advanced GAS type-specific vaccines may be limited, and efforts must be directed to protect against disease in regions of high incidence.

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Citations

Mar 21, 2017·Vaccine·Florian SchödelJonathan Carapetis
Jan 9, 2018·Journal of the Pediatric Infectious Diseases Society·Natasha S ChingAndrew C Steer
Sep 17, 2016·Nature Communications·John A LeesJukka Corander
Nov 22, 2018·Journal of the Pediatric Infectious Diseases Society·Ruth Link-GellesChris Van Beneden
Mar 5, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ngure KagiaSusan C Morpeth
Jan 10, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Johan VekemansDavid C Kaslow
Feb 25, 2020·The Pediatric Infectious Disease Journal·Elise ThielemansAndrew C Steer
Aug 16, 2018·Open Forum Infectious Diseases·Gregory J TyrrellChristopher Bell
Oct 17, 2017·The Lancet Infectious Diseases·Phoebe C M WilliamsJames A Berkley
Sep 8, 2018·Microbiology Spectrum·Debra E BessenBernard W Beall
Mar 7, 2017·Vaccine·Birgitte K GiersingUNKNOWN WHO Product Development for Vaccines Advisory Committee

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Methods Mentioned

BETA
PCR
electrophoresis
biopsy

Software Mentioned

BLAST
FastTree
STATA

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