Invasive Lobular Carcinoma of the Breast with Extracellular Mucin: Case Report of a New Variant of Lobular Carcinoma of the Breast

Case Reports in Pathology
M BoukhechbaB El Khannoussi

Abstract

Invasive carcinoma of no special type (NST) or ductal carcinoma is the largest group of invasive breast cancers. Invasive lobular carcinoma (ILC) is the second most common histological type; it comprises 5%-15% of all invasive breast cancers. Historically, lobular neoplasia and invasive lobular carcinoma may produce intracellular mucin that pushes the nucleus to one side, creating the characteristic signet ring cell morphology. The extracellular mucin secretion is essentially described in mucinous breast carcinoma. Mucinous differentiation can be seen in small areas of NST carcinoma, but recently a few cases of invasive lobular carcinoma with extracellular mucin are reported in the literature. It is important for pathologists to recognize this new entity because it mimics a NST carcinoma, as such a diagnosis may require a different approach in clinical management and surveillance. We report a new case of ILC with extracellular mucin and a review of the literature.

References

May 23, 2014·Histopathology·Puay Hoon TanSunil R Lakhani
May 30, 2015·Journal of Clinical and Diagnostic Research : JCDR·Vaibhav Bhika BariKavita Chandrahas Sane
Jun 18, 2016·International Journal of Surgery Case Reports·G S Gómez MacíasI García Hernández

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Citations

May 19, 2020·The Breast Journal·Paula S GinterSandra J Shin
Dec 8, 2020·Frontiers in Oncology·Asadoor Amirkhani NamagerdiAntonio Giordano

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Methods Mentioned

BETA
biopsy

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