Invasive melanoma in a 5-year-old Canadian patient: A case report

SAGE Open Medical Case Reports
Joanna YuenLoretta Fiorillo

Abstract

Atypical Spitzoid lesions pose a distinct challenge in classification as they may comprise a mixture of both classic benign nevus and cutaneous melanoma characteristics. Immunostaining and molecular analysis, such as comparative genomic hybridization, can assist in narrowing the differential diagnosis. We present a case of a 5-year-old male with an atypical Spitzoid lesion on his back. Initial histopathology revealed a relatively symmetric lesion with mitotic figures and poor maturation of melanocytes with descent into the dermis. Immunohistochemistry demonstrated a loss of p16, and array comparative genomic hybridization revealed a loss of chromosome 9, supporting a diagnosis of invasive melanoma arising in conjunction with a remnant of a conventional melanocytic nevus. This case is the first in Canada to demonstrate the use of array comparative genomic hybridization for diagnosing melanoma in a young paediatric patient.

References

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Jan 25, 2011·Journal of the American Academy of Dermatology·Wynnis L TomSheila Fallon Friedlander
Feb 18, 2011·Journal of Cutaneous Pathology·Timothy H McCalmontBoris C Bastian
Jun 19, 2013·International Journal of Surgical Pathology·Gerardo FerraraAnnalisa Patrizi
Apr 23, 2016·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jeong Hee Cho-Vega
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Methods Mentioned

BETA
biopsy
dissection

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