Invasive non-typeable Haemophilus influenzae infection due to endometritis associated with adenomyosis

BMC Infectious Diseases
Yoshito NishimuraFumio Otsuka

Abstract

The widespread administration of the Haemophilus influenzae type b vaccine has led to the predominance of non-typable H. influenzae (NTHi). However, the occurrence of invasive NTHi infection based on gynecologic diseases is still rare. A 51-year-old Japanese woman with a history of adenomyoma presented with fever. Blood cultures and a vaginal discharge culture were positive with NTHi. With the high uptake in the uterus with 67Ga scintigraphy, she was diagnosed with invasive NTHi infection. In addition to antibiotic administrations, a total hysterectomy was performed. The pathological analysis found microabscess formations in adenomyosis. Although NTHi bacteremia consequent to a microabscess in adenomyosis is rare, this case emphasizes the need to consider the uterus as a potential source of infection in patients with underlying gynecological diseases, including an invasive NTHi infection with no known primary focus.

References

Jan 1, 1991·Scandinavian Journal of Infectious Diseases·H SchønheyderT Ejlertsen
Jun 28, 2008·The Lancet Infectious Diseases·Shaun K MorrisNeal Halsey
Mar 30, 2013·Diagnostic Microbiology and Infectious Disease·David MartinJeannette Guarner
Mar 20, 2014·JAMA : the Journal of the American Medical Association·Sarah CollinsShamez N Ladhani
Apr 27, 2017·Zhonghua fu chan ke za zhi·T J BaiH L Zhu
Jun 18, 2017·The Journal of Obstetrics and Gynaecology Research·Xiao ChenXiaofeng Zhao
Apr 25, 2019·Curēus·Nida SajjadShaista Afzal
Dec 28, 2019·Pediatrics International : Official Journal of the Japan Pediatric Society·Daisuke HaramaHisatake Ikeda

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Methods Mentioned

BETA
hysterectomy
biopsy

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