Invasive non-typhoidal salmonella disease: an emerging and neglected tropical disease in Africa.

Lancet
Nicholas A FeaseyMelita A Gordon

Abstract

Invasive strains of non-typhoidal salmonellae have emerged as a prominent cause of bloodstream infection in African adults and children, with an associated case fatality of 20-25%. The clinical presentation of invasive non-typhoidal salmonella disease in Africa is diverse: fever, hepatosplenomegaly, and respiratory symptoms are common, and features of enterocolitis are often absent. The most important risk factors are HIV infection in adults, and malaria, HIV, and malnutrition in children. A distinct genotype of Salmonella enterica var Typhimurium, ST313, has emerged as a new pathogenic clade in sub-Saharan Africa, and might have adapted to cause invasive disease in human beings. Multidrug-resistant ST313 has caused epidemics in several African countries, and has driven the use of expensive antimicrobial drugs in the poorest health services in the world. Studies of systemic cellular and humoral immune responses in adults infected with HIV have revealed key host immune defects contributing to invasive non-typhoidal salmonella disease. This emerging pathogen might therefore have adapted to occupy an ecological and immunological niche provided by HIV, malaria, and malnutrition in Africa. A good understanding of the epidemiology of...Continue Reading

References

Jan 1, 1977·Scandinavian Journal of Infectious Diseases·K O AlausaE Sobayo
Jan 1, 1975·Archives of Disease in Childhood·M B Duggan, L Beyer
Mar 1, 1975·The Journal of Pediatrics·G M Lazarus, H C Neu
Sep 1, 1987·Medicine·J I CohenG R Corey
May 1, 1986·The Journal of Infection·C L LeenP L Yap
Jun 1, 1987·The Journal of Infectious Diseases·D C MabeyB M Greenwood
Apr 1, 1985·Archives of Internal Medicine·S ProfetaS M Smith
Sep 1, 1974·Medicine·C E CherubinN Bellen
Aug 1, 1971·Archives of Internal Medicine·Heonir RochaCharles D Hearey
Jan 1, 1967·Transactions of the Royal Society of Tropical Medicine and Hygiene·J Neves, N R Martins
Mar 19, 1983·Lancet·N ClumeckL Marcelis
Jun 1, 1984·Diagnostic Microbiology and Infectious Disease·E J BottoneF P Duncanson
Mar 31, 1983·The New England Journal of Medicine·G OffenstadtP Lesavre
Feb 1, 1980·The Journal of Infectious Diseases·P T LoVerdeG I Higashi
Mar 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R GruenewaldJ Chan
Jan 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D GendrelD Richard-Lenoble
Jun 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J GalofréJ Mallolas
Feb 1, 1996·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·S SwindellsH E Gendelman
Nov 27, 1998·British Medical Bulletin·C F Gilks
Sep 16, 1999·Molecular Biology and Evolution·J O Andersson, S G Andersson
Sep 7, 2000·Transactions of the Royal Society of Tropical Medicine and Hygiene·S M GrahamM E Molyneux
Feb 15, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·E L Hohmann
Mar 10, 2001·Nature·S T ColeB G Barrell
Apr 26, 2001·The New England Journal of Medicine·F Y LinS C Szu
Jan 5, 2002·Microbes and Infection·M A Jepson, M A Clark
Nov 29, 2002·The New England Journal of Medicine·Christopher M ParryJeremy J Farrar
Dec 23, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Melita A GordonLisette van Lieshout
Aug 12, 2004·Tropical Medicine & International Health : TM & IH·Remco P H PetersDavid K Lewis
Oct 23, 2004·The Journal of Infectious Diseases·Calman MacLennanDinakantha S Kumararatne
Jan 7, 2005·The New England Journal of Medicine·James A BerkleyJ Anthony G Scott
Jun 14, 2005·Annals of Tropical Paediatrics·J MilledgeE M Molyneux
Nov 8, 2005·Lancet·Buddha Basnyat
Mar 3, 2006·The Pediatric Infectious Disease Journal·Andrew J BrentJames A Berkley
Oct 25, 2006·Proceedings of the National Academy of Sciences of the United States of America·Michael A FischbachKelly D Smith
Nov 25, 2006·Science·Philippe RoumagnacMark Achtman
Feb 15, 2007·The Journal of Infectious Diseases·Rachel N BronzanStephen M Graham
Mar 1, 2007·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Christian PitterJonathan Mermin
Aug 9, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Chien-Ching HungShan-Chwen Chang
Mar 4, 2008·Tropical Medicine & International Health : TM & IH·Evanson Mweu, Mike English

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Citations

Nov 5, 2013·Microbes and Infection·Pietro Mastroeni, Andrew Grant
Apr 23, 2013·Trends in Parasitology·Susanne van SantenAndré J A M van der Ven
May 10, 2013·The New England Journal of Medicine·Allen G P RossDonald P McManus
Jun 21, 2013·Journal of Clinical Microbiology·Fen QuDongsheng Zhou
Jan 10, 2014·PloS One·Ana Herrero-FresnoRene S Hendriksen
Oct 12, 2012·PLoS Pathogens·Hanna K de JongW Joost Wiersinga
Dec 4, 2012·Mediterranean Journal of Hematology and Infectious Diseases·Richard-Fabian Schumacher, Elena Spinelli
Jan 8, 2014·Iranian Red Crescent Medical Journal·Yasemin AkkoyunluTuran Aslan
Dec 18, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Holly M BiggsJohn A Crump
Jan 25, 2013·Proceedings of the National Academy of Sciences of the United States of America·Andreas KupzRichard A Strugnell
Aug 27, 2013·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M-F PhobaJ Jacobs
Jan 5, 2014·Carbohydrate Research·Francesca MicoliCalman A Maclennan
Jan 21, 2014·The Journal of Infectious Diseases·Tonney S NyirendaRobert S Heyderman
Jun 1, 2014·The Journal of Antimicrobial Chemotherapy·Stije J LeopoldConstance Schultsz
Sep 11, 2014·Annual Review of Microbiology·Gordon Dougan, Stephen Baker
Jul 19, 2014·Comparative Immunology, Microbiology and Infectious Diseases·Aruna PandaLouis J DeTolla
Jun 25, 2014·Acta Biotheoretica·Elaheh Zadeh HosseingholiSeyed Latif Mousavi Gargari
Dec 17, 2014·Foodborne Pathogens and Disease·Luma AkilRemata S Reddy
Oct 11, 2014·Transactions of the Royal Society of Tropical Medicine and Hygiene·John A Crump, Robert S Heyderman
Oct 24, 2014·Emerging Infectious Diseases·Nicholas A FeaseyRobert A Kingsley
Jan 30, 2013·The American Journal of Tropical Medicine and Hygiene·Daniel T LeungEdward T Ryan
Apr 18, 2013·Current Opinion in Infectious Diseases·Alastair C McGregorAndrew J Pollard
Feb 26, 2013·Journal of Reproductive Immunology·Lakshmi KrishnanScott McComb
Apr 20, 2013·Pediatrics and Neonatology·Hung-Ming ChenCheng-Hsun Chiu
Feb 18, 2016·Journal of Tropical Medicine·Christian Diamant Mossoro-KpindeThierry Frank
Mar 5, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ligia M Cruz EspinozaJürgen May
Mar 5, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Justin ImVera von Kalckreuth
Mar 5, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Daniel EibachJürgen May

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Methods Mentioned

BETA
PCR

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