Invasive non-typhoidal Salmonella in sickle cell disease in Africa: is increased gut permeability the missing link?

Journal of Translational Medicine
Seah H LimStephen K Obaro

Abstract

Non-typhoidal Salmonella usually induces self-limiting gastroenteritis. However, in many parts of Africa, especially in individuals who are malnourished, infected with malaria, or have sickle cell disease, the organism causes serious and potentially fatal systemic infections. Since the portal of entry of non-typhoidal Salmonella into the systemic circulation is by way of the intestine, we argue that an increased gut permeability plays a vital role in the initiation of invasive non-typhoidal Salmonella in these patients. Here, we will appraise the evidence supporting a breach in the intestinal barrier and propose the mechanisms for the increased risks for invasive non-typhoidal Salmonella infections in these individuals.

References

Jun 9, 1994·The New England Journal of Medicine·O S PlattP P Klug
Sep 25, 1999·Journal of Leukocyte Biology·L R LardA J Duits
Apr 27, 2000·The Pediatric Infectious Disease Journal·A L WalshM E Molyneux
Sep 7, 2000·Transactions of the Royal Society of Tropical Medicine and Hygiene·S M GrahamM E Molyneux
Feb 5, 2002·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·J P de ChadarévianC Dampier
Mar 7, 2002·Proceedings of the National Academy of Sciences of the United States of America·Aslihan TurhanPaul S Frenette
Aug 2, 2002·Postgraduate Medical Journal·Anita KarimA S Multz
May 31, 2003·Food Additives and Contaminants·J J MalagoJ E van Dijk
Jul 5, 2003·Lancet·Robert E BlackJennifer Bryce
May 28, 2004·American Journal of Hematology·Aaron F H LumScott I Simon
Jan 7, 2005·The New England Journal of Medicine·James A BerkleyJ Anthony G Scott
Feb 26, 2005·BMJ : British Medical Journal·Graham R Serjeant
Jun 14, 2005·Annals of Tropical Paediatrics·J MilledgeE M Molyneux
Nov 1, 2005·Proceedings of the National Academy of Sciences of the United States of America·Fabio BagnoliManuel R Amieva
Mar 3, 2006·The Pediatric Infectious Disease Journal·Andrew J BrentJames A Berkley
May 1, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Melita A GordonMalcolm E Molyneux
Jan 10, 2009·The Pediatric Infectious Disease Journal·Betuel SigaúquePedro L Alonso
Jun 25, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·James A BerkleyCharles R J C Newton
Dec 8, 2009·Proceedings of the National Academy of Sciences of the United States of America·Tarun BansalArul Jayaraman
Jun 1, 2010·The Lancet Infectious Diseases·Elizabeth A ReddyJohn A Crump
Aug 26, 2010·Current Opinion in Infectious Diseases·Stephen M Graham
May 3, 2011·Gastroenterology·Benoit Chassaing, Arlette Darfeuille-Michaud
May 21, 2011·BMC Infectious Diseases·Stephen ObaroRichard Adegbola
Aug 23, 2011·Current Opinion in Immunology·Janet ChowSarkis K Mazmanian
Apr 27, 2012·Pediatric Blood & Cancer·Banu Aygun, Isaac Odame
Feb 15, 2013·PloS One·Gregor GorkiewiczChristoph Högenauer
Apr 23, 2013·Trends in Parasitology·Susanne van SantenAndré J A M van der Ven
Jul 12, 2013·Science Translational Medicine·Ivan Vujkovic-CvijinJoseph M McCune
Nov 12, 2013·Trends in Parasitology·Aubrey J CunningtonMichael Walther
Oct 31, 2014·Pediatric Research·Anne V KaneHonorine D Ward
Nov 20, 2014·BMC Gastroenterology·Stephan C BischoffJerry M Wells
Dec 30, 2014·The European Respiratory Journal·Isabel Moreno-IndiasRamon Farré

❮ Previous
Next ❯

Methods Mentioned

BETA
histone acetylation

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Related Papers

Expert Review of Anti-infective Therapy
Calman A MacLennan, Myron M Levine
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Calman A MacLennan
The Pediatric Infectious Disease Journal
S M GrahamC A Hart
Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Takaaki YoshikawaAkihisa Fukuda
© 2022 Meta ULC. All rights reserved