PMID: 8602001Mar 16, 1996Paper

Invasive pneumococcal disease in a cohort of predominantly HIV-1 infected female sex-workers in Nairobi, Kenya

Lancet
C F GilksF A Plummer

Abstract

HIV infection is a major risk factor for pneumococcal disease in industrialised countries. Although both are common infections in sub-Saharan Africa, few studies have investigated the importance of this interaction. We have followed up a cohort of female sex-workers in Nairobi and report here on the extent of invasive pneumococcal disease. A well-established cohort of low-class female sex-workers, based around a community clinic, was followed up from October, 1989, to September, 1992. 587 participants were HIV positive and 132 remained HIV negative. Set protocols were used to investigate common presentations. Cases were identified clinically and radiographically. Streptococcus pneumoniae and other pathogens were diagnosed by culture. Seventy-nine episodes of invasive pneumococcal disease were seen in the 587 HIV-positive women compared with one episode in the 132 seronegative women (relative risk 17.8, 95% CI 2.5 to 126.5). In seropositive women the incidence rate was 42.5 per 1000 person-years and the recurrence rate was 264 per 1000 person-years. By serotyping, most recurrent events were re-infection. A wide spectrum of HIV-related pneumococcal disease was seen: only 56% of cases were pneumonia; sinusitis was seen in 30% of c...Continue Reading

References

Oct 9, 1975·The New England Journal of Medicine·F O EvansJ M Gwaltney
Aug 1, 1992·The American Journal of Medicine·E W GodofskyC S Weikel
Aug 15, 1992·Annals of Internal Medicine·E N JanoffP C Hopewell
Oct 1, 1988·Australian and New Zealand Journal of Medicine·D J BarnesJ D Igo
Mar 1, 1995·The Journal of Infectious Diseases·O A AnzalaF A Plummer
Apr 1, 1995·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·D J MartinK Keddy
Aug 1, 1994·Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·G Aderaye
Aug 1, 1993·Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·P NunnK McAdam

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Citations

Jun 1, 1979·Social Science & Medicine·C W Hartwig
Jul 4, 2006·Transactions of the Royal Society of Tropical Medicine and Hygiene·Neil A MartinsonMartin Smith
Oct 3, 2001·Transactions of the Royal Society of Tropical Medicine and Hygiene·N J HargreavesS B Squire
Sep 24, 1999·Transactions of the Royal Society of Tropical Medicine and Hygiene·P M KellyJ M Kaldor
May 18, 1996·Lancet·P DomingoG Prats
Feb 19, 2002·International Journal of Antimicrobial Agents·Helena K Parsons, David H Dockrell
Mar 14, 2003·The Journal of Infection·Neil French
Dec 14, 2007·The New England Journal of Medicine·Matthew ScarboroughEduard E Zijlstra
Mar 5, 2010·The New England Journal of Medicine·Neil FrenchCharles F Gilks
Jun 22, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·G ArthurC F Gilks
Jul 31, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A S KarstaedtH H Crewe-Brown
Apr 10, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Elizabeth L CorbettKevin M De Cock
Feb 21, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Charles B HolmesKenneth A Freedberg
Nov 14, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hidehiko TakahashiTsuyoshi Nagatake
May 24, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Shungu S MunyatiElizabeth L Corbett
May 23, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Roger EaganStephen B Gordon
Jun 25, 1999·AIDS Research and Human Retroviruses·E N JanoffM R Wallace
Jan 11, 2008·AIDS Research and Human Retroviruses·Catherine SeylerXavier Anglaret
Aug 1, 1997·AIDS Patient Care and STDs·T L Katzenstein
Oct 1, 1997·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·E N Janoff, J B Rubins
Mar 29, 2002·AIDS·Xavier AnglaretUNKNOWN ANRS 059-Cotrimo-CI study group
Apr 16, 2002·AIDS·Neil FrenchCharles F Gilks
Dec 22, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·F N SsaliJ L Johnson
Feb 21, 2013·Current Opinion in Pulmonary Medicine·Santino Capocci, Marc Lipman
Nov 21, 2007·AIDS·Philippe LespritUNKNOWN ANRS 114-Pneumovac Study Group
May 29, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·K Z VardakasM E Falagas
Dec 16, 2003·BMC Infectious Diseases·Stephen B GordonMalcolm E Molyneux
Feb 4, 2010·PloS One·Catherine HyamsStephen B Gordon

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