PMID: 15247603Jul 13, 2004Paper

Invasive pneumococcal infections among hospitalized children in Bamako, Mali

The Pediatric Infectious Disease Journal
James D CampbellMyron Levine

Abstract

Prevention of invasive pneumococcal disease (IPD) in children is a global public health priority, and determination of the most common serotypes is crucial for vaccine development and implementation. We performed prospective surveillance for IPD in hospitalized children in Bamako, Mali. All febrile children and others suspected to have invasive bacterial disease had an admission blood culture and cultures of additional anatomic sites when indicated. Standard microbiologic methods were used to identify, serotype and determine antibiograms for pneumococcal isolates. Of 2,049 children enrolled, 106 (5%) had an IPD, including 47 cases of meningitis and 44 bacteremic pneumonias. The incidence was highest in infants (84/100,000/year). The overall IPD case fatality rate was 24%. Only 2 of 96 isolates were nonsusceptible to penicillin. The serotypes isolated were 5 (54%), 2 (14%), 7F (10%), 19F (8%), 6A/B (3%), 9V (3%), 1 (2%) and 14 (1%). IPD is common and frequently fatal among hospitalized children in Mali, but surprisingly little resistance has occurred. Notably, 91% of the serotypes causing IPD in Bamako children are found in the 11-valent pneumococcal conjugate vaccine.

References

Jul 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P C Appelbaum
Aug 1, 1992·American Journal of Diseases of Children·I R Friedland, K P Klugman
Jan 1, 1986·Pediatric Infectious Disease·M KoskelaP H Mäkelä
Mar 1, 1986·Pediatric Infectious Disease·F Shann
Nov 1, 1994·The Pediatric Infectious Disease Journal·R A AdegbolaE K Mulholland
Aug 1, 1993·Journal of Clinical Microbiology·U B Sørensen
May 1, 1996·The Pediatric Infectious Disease Journal·T J O'DempseyB Greenwood
Sep 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R E FrankelG Friedland
Feb 12, 1998·The New England Journal of Medicine·A SchuchatB A Perkins
Dec 24, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·H H Crewe-BrownK P Klugman
Feb 20, 1998·The Pediatric Infectious Disease Journal·S UsenB Greenwood
Dec 30, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J A ScottK Marsh
Aug 12, 1999·Tropical Medicine & International Health : TM & IH·L Muhe, K P Klugman
Sep 24, 1999·The Pediatric Infectious Disease Journal·H R ShinefieldJ Hansen
Jan 5, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·W P HausdorffG R Siber
Apr 13, 2001·JAMA : the Journal of the American Medical Association·K A RobinsonUNKNOWN Active Bacterial Core Surveillance (ABCs)/Emerging Infections Program Network
Dec 12, 2001·The Pediatric Infectious Disease Journal·S B BlackF Malinoski
Jan 23, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M Catherine McEllistremLee H Harrison
Dec 19, 2002·The Pediatric Infectious Disease Journal·Rosanna LagosMyron M Levine
Jan 25, 2003·Antimicrobial Agents and Chemotherapy·Nadjia Ramdani-Bouguessa, Kheira Rahal
May 2, 2003·The New England Journal of Medicine·Cynthia G WhitneyUNKNOWN Active Bacterial Core Surveillance of the Emerging Infections Program Network
May 1, 1964·Annals of Internal Medicine·R AUSTRIAN, J GOLD
Oct 3, 2003·The New England Journal of Medicine·Keith P KlugmanUNKNOWN Vaccine Trialists Group

❮ Previous
Next ❯

Citations

Jun 27, 2013·Environmental Geochemistry and Health·L WangJ P Bloomfield
Feb 24, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jennifer C MoïsiBradford D Gessner
Jan 22, 2005·Current Opinion in Pediatrics·Paul McCarthy
Jul 30, 2011·The Pediatric Infectious Disease Journal·Peter NyasuluUNKNOWN Group for Enteric, Respiratory and Meningeal Diseases Surveillance in South Africa (GERMS-SA)
Jul 19, 2006·Clinical Microbiology Reviews·Jonathan A McCullers
Apr 21, 2012·Emerging Infectious Diseases·Gregory J TyrrellThomas J Marrie
Aug 26, 2006·Tropical Medicine & International Health : TM & IH·A RocaP Alonso
Jul 11, 2006·Tropical Medicine & International Health : TM & IH·Richard A AdegbolaTumani Corrah
Jan 17, 2013·Tropical Medicine & International Health : TM & IH·G D KinaboP W M Hermans
Apr 8, 2011·Tropical Medicine & International Health : TM & IH·John A CrumpGrace D Kinabo
Jul 20, 2010·Tropical Medicine & International Health : TM & IH·Aatekah OwaisAnita K M Zaidi
Oct 10, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Milagritos D TapiaMyron M Levine
Jun 13, 2006·Lancet·Orin S LevineFelicity Cutts
Sep 4, 2012·Vaccine·S Ben-ShimolUNKNOWN Israeli Bacteremia and Meningitis Active Surveillance Group
Nov 9, 2016·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Lydiane AgierHélène Broutin
Jun 1, 2014·The Journal of Antimicrobial Chemotherapy·Stije J LeopoldConstance Schultsz
Dec 28, 2017·The American Journal of Tropical Medicine and Hygiene·Fabien J FucheSharon M Tennant
Jul 25, 2009·Expert Review of Vaccines·Stephen Obaro
Jul 25, 2009·Expert Review of Vaccines·Ener Cagri Dinleyici, Zeynel Abidin Yargic
Dec 18, 2010·Expert Review of Vaccines·E David G McIntosh, Ralf R Reinert
Nov 4, 2009·Expert Review of Anti-infective Therapy·Ener Cagri Dinleyici, Zeynel Abidin Yargic

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Meningitis

Bacterial meningitis continues to be an important cause of mortality and morbidity throughout the world. Here is the latest research.

Bacterial Meningitis (ASM)

Bacterial meningitis continues to be an important cause of mortality and morbidity throughout the world. Here is the latest research.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.