Invasive Pulmonary Aspergillosis-mimicking Tuberculosis

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Sung-Han KimJun Hee Woo

Abstract

Pulmonary tuberculosis is occasionally confused with invasive pulmonary aspergillosis (IPA) in transplant recipients, since clinical suspicion and early diagnosis of pulmonary tuberculosis and IPA rely heavily on imaging modes such as computed tomography (CT). We therefore investigated IPA-mimicking tuberculosis in transplant recipients. All adult transplant recipients who developed tuberculosis or IPA at a tertiary hospital in an intermediate tuberculosis-burden country during a 6-year period were enrolled. First, we tested whether experienced radiologists could differentiate pulmonary tuberculosis from IPA. Second, we determined which radiologic findings could help us differentiate them. During the study period, 28 transplant recipients developed pulmonary tuberculosis after transplantation, and 80 patients developed IPA after transplantation. Two experienced radiologists scored blindly 28 tuberculosis and 50 randomly selected IPA cases. The sensitivities of radiologists A and B for IPA were 78% and 68%, respectively (poor agreement, kappa value = 0.25). The sensitivities of radiologists A and B for tuberculosis were 64% and 61%, respectively (excellent agreement, kappa value = 0.77). We then compared the CT findings of the 2...Continue Reading

References

Sep 1, 1994·The Journal of Infectious Diseases·L A CollinsA W Karchmer
Apr 1, 1993·AJR. American Journal of Roentgenology·K S LeeB H Lee
Aug 7, 1998·AJR. American Journal of Roentgenology·J CollinsE J Stern
Nov 25, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·N Singh, D L Paterson
Dec 20, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nina SinghPeter Linden
Aug 28, 2003·European Radiology·P Van DyckA M De Schepper
Jan 18, 2005·Clinical Microbiology Reviews·Nina Singh, David L Paterson
Feb 16, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Patricia MuñozEmilio Bouza
Jun 7, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J GavaldaUNKNOWN RESITRA (Spanish Network for Research on Infection in Transplantation)
Jan 6, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Reginald E GreeneRobert H Rubin
Jan 16, 2008·Radiology·David M HansellJacques Remy
May 9, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ben De PauwUNKNOWN National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group
Feb 27, 2009·Journal of Thoracic Imaging·Jung Im JungSeog Hee Park
Mar 27, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·José María AguadoPatricia Muñoz
May 19, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Julián Torre-CisnerosUNKNOWN Spanish Network for Research in Infectious Diseases
Dec 17, 2009·Transplant Infectious Disease : an Official Journal of the Transplantation Society·D Lopez de Castilla, N W Schluger
Mar 24, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Seong Yeon ParkSung-Han Kim
Jul 1, 2011·The Korean Journal of Internal Medicine·Dong-Gun LeeJung-Hyun Choi
Jul 14, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S-H KimD J Han
Oct 12, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Yu-Mi LeeSung-Han Kim

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Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.