Invasive pulmonary fungal infection in hematologic patients: is resection effective?

The Hematology Journal : the Official Journal of the European Haematology Association
J M HabichtM Tamm

Abstract

Invasive pulmonary aspergillosis carries a high mortality in neutropenic patients. Descriptive reports have shown early surgery to be feasible with acceptably low morbidity. The possible benefit of surgery has not been investigated in comparative studies. In a retrospective cohort study encompassing a 15-year period, 54 (8%) of 697 consecutive patients with severe hematological disease required treatment for localized invasive pulmonary aspergillosis. Patients treated by antifungal drugs (medical group, n = 24) were compared to patients treated with additional early lung resection (surgical group, n = 30). Outcomes analysed were fungal progression and survival. Fungal progression at six months was 17% (95% CI 3-31) in the surgical group and 52% (95% CI 34-73) in the medical group (P = 0.005). Survival at six months was 70% (95% CI 53-87) in surgically and 42% (95% CI 24-62) in medically treated patients (P = 0.009). Adjusting for differences in WHO performance score (worse in the medical group) and duration of neutropenia (longer in the surgical group) in a multivariate analysis, a difference in relative risk of death (0.26; 95% CI 0.08-0.88; P = 0.03) remained in favor of surgery. In this retrospective study surgical intervent...Continue Reading

Citations

Aug 19, 2005·Expert Review of Anti-infective Therapy·S R DoffmanJeremy S Brown
Nov 19, 2013·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Masatsugu HamajiClaude Deschamps
Feb 9, 2008·Drugs·Suganthini Krishnan-Natesan, Pranatharthi H Chandrasekar

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