Invasive Serotype 35B Pneumococci Including an Expanding Serotype Switch Lineage, United States, 2015-2016

Emerging Infectious Diseases
S ChochuaBernard Beall

Abstract

We used whole-genome sequencing to characterize 199 nonvaccine serotype 35B pneumococcal strains that caused invasive pneumococcal disease (IPD) in the United States during 2015-2016 and related these findings to previous serotype 35B IPD data obtained by Active Bacterial Core surveillance. Penicillin-nonsusceptible 35B IPD increased during post-pneumococcal 7-valent conjugate vaccine years (2001-2009) and increased further after implementation of pneumococcal 13-valent conjugate vaccine in 2010. This increase was caused primarily by the 35B/sequence type (ST) 558 lineage. 35B/ST558 and vaccine serotype 9V/ST156 lineages were implicated as cps35B donor and recipient, respectively, for a single capsular switch event that generated emergent 35B/ST156 progeny in 6 states during 2015-2016. Three additional capsular switch 35B variants were identified, 2 of which also involved 35B/ST558 as cps35B donor. Spread of 35B/ST156 is of concern in view of past global predominance of pathogenic ST156 vaccine serotype strains. Protection against serotype 35B should be considered in next-generation pneumococcal vaccines.

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Oct 13, 2017·Expert Opinion on Biological Therapy·Nicola Principi, Susanna Esposito
Mar 15, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Corinne LevyRobert Cohen
Oct 15, 2019·Microbial Genomics·Tamsin C M DewéNicholas J Croucher
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Nov 13, 2021·Frontiers in Cellular and Infection Microbiology·Naoko FujiRavinder Kaur
Oct 6, 2017·Pediatrics·Douglas S Swanson, Christopher J Harrison

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Methods Mentioned

BETA
Serotyping
acetylation

Software Mentioned

RaxML
eBURST
VelvetK
kSNP3
VelvetOptimiser
Cutadapt

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