Abstract
Objective: To investigate the clinicopathologic features and immunophenotype of invasive-stratified mucin-producing carcinoma (ISMC). Methods: We retrospectively analyzed three patients who underwent surgery for pathologically confirmed ISMC from January 2017 to December 2017 in Anyang Tumor Hospital. The pathological features, immunophenotype, and prognosis were discussed. Results: Clinical symptoms and imaging were atypical. Microscopically, the arrangement of tumor cells is close to that of squamous cell carcinoma, showing flake or nested growth. Morphologically, tumor cells were reminiscent of adenocarcinoma. The tumor cells showed abundant intracytoplasmic mucus which routinely created spacing between adjacent nuclei. The nuclei was round or oval with irregular karyotypes, thick nuclear membrane, staining empty light, rough chromatin, visible small nucleoli. Mucous vacuoles or pink-stained foam were visible in the cytoplasm. Mitotic features and apoptotic bodies were seen in the invasive component of all three cases, whereas all but one of these showed a neutrophil-dominant inflammatory cells infiltration. A large number of histocytes were found in the stroma of two cases. Special staining of mucus confirmed the presence o...Continue Reading
References
May 1, 1976·Cancer·P LittmanR E Scully
Mar 1, 1992·Gynecologic Oncology·R J LotockiF K Fung
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·S M BaileyP Workman
Jan 1, 1990·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·W L ThelmoJ Boyce
Jan 1, 1993·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·T J ColganJ R McLaughlin
Jul 10, 1998·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·R A SamlalF B Lammes
Oct 7, 2000·The American Journal of Surgical Pathology·J J ParkC P Crum
Jul 4, 2006·The Lancet Oncology·Zhong JiangChin-Lee Wu
Dec 29, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Cuizhen LiKaren Dresser
Mar 19, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lioudmila SitnikovaZhong Jiang
Apr 11, 2008·Taiwanese Journal of Obstetrics & Gynecology·Tian-Lun HsuChia-Yu Ou
Aug 22, 2009·Human Pathology·Otto WalterAshraf Khan
Oct 30, 2013·Histopathology·Christopher D M Fletcher
Jul 22, 2014·Histopathology·David P Boyle, W Glenn McCluggage
Sep 12, 2015·International Journal of Surgical Pathology·Guido BellezzaAngelo Sidoni
Nov 3, 2015·The American Journal of Surgical Pathology·Ricardo R LastraJ Kenneth Schoolmeester
May 31, 2016·Human Pathology·Junji OnishiYujiro Asada
Jun 28, 2017·OncoTargets and Therapy·Luyao ChenXu Zhang