Inverse association between farm animal contact and respiratory allergies in adulthood: protection, underreporting or selection?

Allergy
Katja RadonDennis Nowak

Abstract

It has been argued that the inverse association between exposure to farm animals and nasal allergies observed in children and adults might be because of self-selection. We aimed to assess the health-based selection out of farming in adults. A cross-sectional study was carried out in a rural region. Overall, 4053 inhabitants (63%) aged 18-44 years responded to a questionnaire on respiratory diseases, life-time exposure to farming environments and potential confounders. For 2678 of these, specific immunoglobulin E to common allergens was available. The outcome was: (i) sensitization and symptoms of nasal allergies (symptomatic sensitization); (ii) sensitization without symptoms of nasal allergies (asymptomatic sensitization). Farm animal contact in childhood was associated with a decreased risk of symptomatic and asymptomatic sensitization. Continued exposure to farm animals in adulthood further decreased the odds ratio of symptomatic (odds ratio 0.2; 95% confidence interval 0.1, 0.4) but not asymptomatic sensitization (0.7; 0.4, 1.1). Starting farm animal contact in adulthood even increased the odds ratio of asymptomatic sensitization (2.4; 1.1, 5.2). The preventive effect of childhood contact to farm animals against sensitizati...Continue Reading

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