Inverse association between statin use and head and neck cancer: Population-based case-control study in Han population

Head & Neck
Li-Ting KaoHerng-Ching Lin

Abstract

This case-control study aimed to find the relationship between prior statin use and head and neck cancer occurrence using a large population-based database. This study used claims data from the Taiwan Longitudinal Health Insurance Database. We included 5515 patients with head and neck cancer as cases and 5515 propensity score-matched patients without head and neck cancer as controls. Conditional logistic regressions were performed to investigate the relationship between head and neck cancer and prior statin exposure. Of the 11 030 total sampled patients, 16.95% had previously received prescriptions for statins. In addition, statin exposure was found in 15.99% of cases and 17.91% of controls. The logistic regression also revealed that the adjusted odds ratio of prior statin exposure for cases was 0.86 (95% confidence interval: 0.77-0.95) compared to propensity score-matched controls. This study found an inverse association between statin usage and head and neck cancer occurrence.

References

May 12, 2001·Science·E S Istvan, J Deisenhofer
Jun 18, 2002·Journal of Cellular and Molecular Medicine·C Stancu, A Sima
Aug 28, 2003·Journal of Cancer Research and Clinical Oncology·Angela J ManthaJim Dimitroulakos
Dec 13, 2005·Nature Reviews. Cancer·Marie-France DemierreScott M Lippman
Jan 5, 2006·JAMA : the Journal of the American Medical Association·Krista M DaleC Michael White
Mar 22, 2006·The Oncologist·Katja HindlerCharles D Collard
May 20, 2008·Lancet·Athanassios ArgirisRobert L Ferris
Aug 19, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Jaana KuoppalaEero Pukkala
May 1, 2012·Cancer Letters·Maja Osmak
Sep 20, 2012·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·I L P BealesT Broughton
Nov 9, 2012·The New England Journal of Medicine·Sune F NielsenStig E Bojesen
Nov 14, 2012·The International Journal of Biochemistry & Cell Biology·Jing ZhangXuefeng Liu
Dec 4, 2013·Anti-cancer Agents in Medicinal Chemistry·Natalia G VallianouChristos Kazazis
Jan 7, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Chenxi ZhongHeng Zhao
May 6, 2014·Oral and Maxillofacial Surgery Clinics of North America·Nadarajah Vigneswaran, Michelle D Williams
Jun 1, 2012·Therapeutic Advances in Drug Safety·Miao HuBrian Tomlinson
Sep 2, 2014·Clinical Endocrinology·Luca Mascitelli, Mark R Goldstein
May 24, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Lucyna MatusewiczAleksander F Sikorski
Jun 23, 2015·PloS One·Ludmila Madeira Cardoso PavanEliete Neves Silva Guerra
Oct 27, 2015·JAMA : the Journal of the American Medical Association·Jason S Haukoos, Roger J Lewis
Nov 20, 2016·International Journal of Cancer. Journal International Du Cancer·Zubing MeiWei Yang
Feb 20, 2017·The Laryngoscope·Sunshine Dwojak, Neil Bhattacharyya

❮ Previous
Next ❯

Citations

Dec 16, 2020·International Journal of Cancer. Journal International Du Cancer·Kayla R GetzAlison M Mondul
Jul 28, 2019·Life Sciences·Ke WangXin-Hua Liang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.