Inverse Association Between Statin Use and Overall Cancer Incidence in Individuals With Hypercholesterolemia, Based on the Korean Health Insurance Service Between 2002 and 2015

Asia-Pacific Journal of Public Health
Joungyoun KimHee-Taik Kang

Abstract

The Korean National Health Insurance Service provided the Health Screening Cohort Database. To investigate the cumulative effect of statins on cancer development, we defined statin users as those who used statins during 2002 to 2003 at baseline. Statin users were divided into high and low users. Statin nonusers were defined as individuals who had never used statins during the entire period of 2002 to 2015, despite having hypercholesterolemia. In total, 17 737 statin users and 13 412 statin nonusers were included in the final analyses. The median follow-up duration was 12.6 years. Compared with nonusers, the hazard ratios (95% confidential intervals) for any cancer incidence of low users and high users were 1.047 (0.941-1.164) and 0.663 (0.589-0.747) in men and 1.057 (0.938-1.190) and 0.592 (0.517-0.678) in women, respectively, after fully adjusting for possible confounding factors. An inverse association between statin use and any cancer incidence in individuals with hypercholesterolemia was observed.

References

Apr 14, 1995·Science·P J Casey
Jun 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matthijs R GraafHenk-Jan Guchelaar
Sep 11, 2004·Lipids·Sarah A Holstein, Raymond J Hohl
Mar 1, 2006·Atherosclerosis. Supplements·Matthias Endres
Aug 10, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stefanos BonovasNikolaos M Sitaras
Aug 19, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Jaana KuoppalaEero Pukkala
Sep 10, 2009·International Journal of Cancer. Journal International Du Cancer·Jari HaukkaJari Tiihonen
Aug 5, 2011·Journal of the National Cancer Institute·Thomas P AhernTimothy L Lash
Dec 14, 2012·BMC Cancer·Jeeyun LeeWon Ki Kang
Jun 12, 2013·European Journal of Clinical Pharmacology·Xiao-Dan WuYan-Qing Chen
Jul 9, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jean A McDougallChristopher I Li
Nov 23, 2013·Cancer Causes & Control : CCC·Yanqiong LiuXue Qin
Aug 13, 2014·Cancer Epidemiology·Katherine A McGlynnSharon Hensley Alford
Oct 1, 2014·The American Journal of Cardiology·Anders GreenTerje R Pedersen
Jun 10, 2016·British Journal of Cancer·Ange WangMarcia L Stefanick
Nov 20, 2016·International Journal of Cancer. Journal International Du Cancer·Gyuri KimEun Seok Kang
Jan 7, 2017·Circulation Research·Adam OesterleJames K Liao
Aug 15, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Signe Benzon LarsenSøren Friis

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