PMID: 9417007Jan 7, 1998Paper

Inverse association of dietary fat with development of ischemic stroke in men

JAMA : the Journal of the American Medical Association
M W GillmanP A Wolf

Abstract

A few ecological and cohort studies in Asian populations suggest an inverse association of the intake of both fat and saturated fat with risk of stroke. However, data among western populations are scant. To examine the association of stroke incidence with intake of fat and type of fat among middle-aged US men during 20 years of follow-up. The Framingham Heart Study, a population-based cohort study. A total of 832 men, aged 45 through 65 years, who were free of cardiovascular disease at baseline (1966-1969). MEASUREMENTS AND DATA ANALYSIS: The diet of each subject was assessed at baseline by a single 24-hour dietary recall, from which intakes of energy and macronutrients were estimated. In Kaplan-Meier analyses, we calculated age-adjusted cumulative incidence rates of stroke. Using Cox regression, we estimated stroke incidence relative risks during 20 years of follow-up. Incidence of ischemic stroke, which occurred in 61 subjects during the follow-up period. Mean intakes were 10975 kJ for energy; 114 g (39% of energy) for total fat; 44 g (15%) for saturated fat; 46 g (16%) for monounsaturated fat; and 16 g (5%) for polyunsaturated fat. Risk of ischemic stroke declined across the increasing quintile of total fat (log-rank trend P...Continue Reading

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