PMID: 9187297May 17, 1997Paper

Inverse correlation between expression of phosphatidylethanolamine N-methyltransferase-2 and growth rate of perinatal rat livers

Biochimica Et Biophysica Acta
Z CuiDennis E Vance

Abstract

Our previous studies have implicated the liver-specific phosphatidylethanolamine N-methyltransferase-2 (PEMT2) in suppression of hepatocarcinoma proliferation (Cui et al. (1994) J. Biol. Chem. 269, 24531-24533). It was not known if this phenomenon in cell culture had relevance to liver growth and PEMT2 expression in an intact animal. Hence, we investigated the relationship between normal proliferation of liver and the expression of PEMT2 during the perinatal period of developing rats. PEMT2 protein was completely absent, and PEMT activity was very low, in prenatal livers in which liver growth is rapid. At birth, a decrease of liver growth coincided with the rapid appearance in liver of a high level of PEMT2 protein that was sustained throughout adult life. Northern blots revealed that the postnatal expression of PEMT2 correlated with the level of its mRNA. Immunohistochemical staining of liver sections showed a distinctive pattern of PEMT2 expression at birth. A high level of PEMT2 was expressed in defined extranuclear regions of hepatocytes from newborn rats whereas the protein was dispersed in the extranuclear areas in adult hepatocytes. The inverse correlation between the rate of liver growth and PEMT2 expression together wi...Continue Reading

References

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Citations

Apr 20, 2005·Brain Research. Molecular Brain Research·Xiaonan Zhu, Steven H Zeisel
Nov 25, 1997·Biochimica Et Biophysica Acta·D E VanceZ Cui
Apr 19, 2002·Biochimica Et Biophysica Acta·Wei ZouZhao-Chun Tsui
Jan 18, 2003·Biochimica Et Biophysica Acta·Zheng Cui, Martin Houweling
Sep 24, 1999·The Biochemical Journal·B A BladergroenL M van Golde
Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·C J WalkeyD E Vance
Apr 19, 2006·In Vitro Cellular & Developmental Biology. Animal·Hisae Kume, Hajime Sasaki
Aug 11, 2012·Biochimica Et Biophysica Acta·Dennis E Vance
Nov 5, 2013·Biochimica Et Biophysica Acta·Dennis E Vance
Jan 29, 2013·Critical Reviews in Biochemistry and Molecular Biology·Neale D Ridgway
Jul 7, 2007·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Valéria Cristina Soares FurtadoAntonio Carlos Iglesias
Sep 8, 2005·The Journal of Biological Chemistry·Zhaoyu LiDennis E Vance
Apr 29, 1998·Current Opinion in Lipidology·D E Vance, C J Walkey
Mar 29, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Melanie C FisherThomas W Sadler
Oct 7, 2020·The American Journal of Clinical Nutrition·Kevin C Klatt
Feb 28, 2002·The Journal of Biological Chemistry·Cynthia J DeLongZheng Cui

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