Inverse correlation of expression of microRNA-140-5p with progression of multiple sclerosis and differentiation of encephalitogenic T helper type 1 cells

Immunology
Hongbing GuanMitzi Nagarkatti

Abstract

The role of microRNA in the regulation of encephalitogenic T-cell development is of interest in understanding the pathogenesis of multiple sclerosis (MS). Direct binding of microRNAs to their target mRNAs usually suppresses gene expression and facilitates mRNA degradation. In this study, we observed that the expression of several microRNAs was significantly altered in patients with MS. Interestingly, the expression of miR-140-5p, among other microRNAs, was significantly decreased in the peripheral blood mononuclear cells of patients with MS, and this microRNA may regulate encephalitogenic T helper type 1 (Th1) cell differentiation. The expression level of miR-140-5p was inversely correlated with disease severity with greater reduction in relapsing disease compared with remitting disease. Transfection of synthetic miR-140-5p in peripheral blood mononuclear cells suppressed encephalitogenic Th1 differentiation. Signal transducer and activator of transcription 1 (STAT1) was the functional target of miR-140-5p - transfection of the synthetic miR-140-5p suppressed activation of STAT1 and the expression of its downstream target, T-bet. Our results suggested that miR-140-5p is probably involved in the regulation of encephalitogenic T ...Continue Reading

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Citations

Sep 18, 2016·Autoimmunity Reviews·Ji-Qing ChenMargit Zeher
Dec 12, 2017·Clinical Case Reports·Annamaria VallelungaTommaso Iannitti
Aug 15, 2019·International Reviews of Immunology·Suyasha Roy, Amit Awasthi
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Dec 1, 2018·Clinical Epigenetics·Xuan YangBing Ni
Jan 29, 2021·Molecular Genetics and Genomics : MGG·Yanjun DingRuijie Zhang
May 18, 2020·International Immunopharmacology·Gholamreza Rezaei DanbaranHamed Mohammadi
Mar 27, 2021·Journal of Translational Medicine·Zijian LiJuan Feng

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