Inverse correlation of HER2 with MHC class I expression on oesophageal squamous cell carcinoma.

British Journal of Cancer
T MaruyamaKoji Kono

Abstract

As HER2 is expressed in 30% of oesophageal squamous cell carcinomas (ESCCs), T-cell-based immunotherapy and monoclonal antibodies targeted against HER2 are attractive, novel approaches for ESCCs. However, it was shown that there is an inverse correlation between HER2 and MHC class I expression on tumours. Thus, the correlation between HER2 and MHC class I expressions on ESCC was evaluated. Expressions of MHC class I and HER2 in ESCC tissues (n=80) and cell lines were assessed by immunohistochemistry, fluorescence in situ hybridisation (FISH), and flow cytometry. We investigated whether HER2 downregulation with small interfering RNA (siRNA) in ESCC cell lines could upregulate the expression of MHC class I and the antigen presentation machinery components, and could increase their sensitivity for tumour antigen-specific CTLs. There was an inverse correlation between HER2 and MHC class I expressions in both tumour tissues and cell lines. Downregulation of HER2 with siRNA resulted in the upregulation of MHC class I expression, leading to increased CTL recognition by tumour antigen-specific CTLs. HER2-overexpressing ESCC tumour cells showed a reduced sensitivity for CTLs through the downregulation of MHC class I.

References

Jun 1, 1991·The Annals of Thoracic Surgery·H KatoT Iizuka
Nov 15, 1985·Science·R S GoodenowR L Linsk
Jul 1, 1994·International Journal of Cancer. Journal International Du Cancer·A La CavaS Fontana
Aug 31, 1995·Nature·M A Reeve, C W Fuller
Sep 1, 1994·Annals of Surgery·H AkiyamaY Kajiyama
Jan 1, 1997·Advances in Cancer Research·M L Disis, M A Cheever
Aug 26, 1998·International Journal of Cancer. Journal International Du Cancer·P L LolliniP Nanni
Oct 1, 1998·International Journal of Cancer. Journal International Du Cancer·K KonoR Kiessling
Jul 31, 2001·International Journal of Cancer. Journal International Du Cancer·A ZiaI Funke
Jul 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Satoshi IshikuraShigeaki Yoshida
Jan 20, 2004·Cancer Research·Felix HerrmannBarbara Seliger
Feb 18, 2004·International Journal of Radiation Oncology, Biology, Physics·Mina D MarmorYosef Yarden
Apr 10, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Koji KonoHideki Fujii
Feb 3, 2005·Breast Disease·Mary L DisisKeith L Knutson
Jul 9, 2005·International Journal of Cancer. Journal International Du Cancer·Nicholas F S WatsonLindy G Durrant
Sep 10, 2005·Cancer Immunology, Immunotherapy : CII·Barbara L F KaplanMichael I Nishimura
Aug 3, 2006·Journal of Clinical Pathology·Khawla Al-KurayaLuigi Tornillo
Jul 2, 2009·International Journal of Cancer. Journal International Du Cancer·Christine SersReinhold Schäfer

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Citations

Nov 5, 2016·Immunology and Cell Biology·Lis N VelásquezPaula Barrionuevo
Dec 20, 2014·Pediatric Blood & Cancer·Kellie B HaworthTimothy P Cripe
Mar 28, 2012·The Journal of Pathology·Irene RomeroAngel M Garcia-Lora
Jul 7, 2016·Clinical & Experimental Metastasis·Omar FahmyGeorgios Gakis
Nov 19, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kousaku MimuraKoji Kono
Apr 23, 2014·Biotechnology and Bioengineering·David J KlinkeChristina Byrne-Hoffman
Apr 11, 2018·Oncoimmunology·Karthikeyan SubbarayanBarbara Seliger
Mar 27, 2021·Frontiers in Immunology·Karthik DhatchinamoorthyKenneth L Rock
Jun 4, 2021·Molecular Immunology·M L M JongsmaR M Spaapen

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Methods Mentioned

BETA
FCS
dissection
flow cytometry
electrophoresis
FACS
transfection

Software Mentioned

PathVysion

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