Inverse gradient of nitrergic and purinergic inhibitory cotransmission in the mouse colon

Acta Physiologica
Noemí MañéM Jiménez

Abstract

Gastrointestinal smooth muscle relaxation is accomplished by the neural corelease of ATP or a related purine and nitric oxide. Contractions are triggered by acetylcholine and tachykinins. The aim of this work was to study whether regional differences in neurotransmission could partially explain the varied physiological roles of each colonic area. We used electrophysiological and myography techniques to evaluate purinergic (L-NNA 1 mm incubated tissue), nitrergic (MRS2500 0.3 μm incubated tissue) and cholinergic neurotransmission (L-NNA 1 mm and MRS2500 0.3 μm incubated tissue) in the proximal, mid and distal colon of CD1 mice (n = 42). Purinergic electrophysiological responses elicited by single pulses (28 V) were greater in the distal (IJPfMAX = -35.3 ± 2.2 mV), followed by the mid (IJPfMAX = -30.6 ± 1.0 mV) and proximal (IJPfMAX = -11.7 ± 1.1 mV) colon. In contrast, nitrergic responses decreased from the proximal colon (IJPsMAX = -11.4 ± 1.1 mV) to the mid (IJPsMAX = -9.1 ± 0.4 mV), followed by the distal colon (IJPsMAX = -1.8 ± 0.3 mV). A similar rank of order was observed in neural mediated inhibitory mechanical responses including electrical field stimulation-mediated responses and neural tone. ADPβs concentration-response...Continue Reading

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Citations

Mar 5, 2016·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Diana GallegoMarcel Jiménez
Mar 27, 2018·Acta Physiologica·Pontus B Persson, A Bondke Persson
Aug 1, 2018·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S FidalgoM S Yeoman
Jun 13, 2019·American Journal of Physiology. Gastrointestinal and Liver Physiology·Vladimir GrubišićBrian D Gulbransen
Dec 18, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Sara TraserraMarcel Jimenez
Dec 4, 2019·American Journal of Physiology. Gastrointestinal and Liver Physiology·Nick J SpencerHongzhen Hu
Jul 15, 2017·American Journal of Physiology. Gastrointestinal and Liver Physiology·Leonie DurninVioleta N Mutafova-Yambolieva
Oct 22, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·N J SpencerJ D Wood
Feb 16, 2021·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Marcello CostaNick J Spencer
Jun 20, 2021·Autonomic Neuroscience : Basic & Clinical·Kenton M Sanders, Violeta N Mutafova-Yambolieva

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