Inverse Monte Carlo in a multilayered tissue model: merging diffuse reflectance spectroscopy and laser Doppler flowmetry

Journal of Biomedical Optics
Ingemar FredrikssonTomas Strömberg

Abstract

The tissue fraction of red blood cells (RBCs) and their oxygenation and speed-resolved perfusion are estimated in absolute units by combining diffuse reflectance spectroscopy (DRS) and laser Doppler flowmetry (LDF). The DRS spectra (450 to 850 nm) are assessed at two source-detector separations (0.4 and 1.2 mm), allowing for a relative calibration routine, whereas LDF spectra are assessed at 1.2 mm in the same fiber-optic probe. Data are analyzed using nonlinear optimization in an inverse Monte Carlo technique by applying an adaptive multilayered tissue model based on geometrical, scattering, and absorbing properties, as well as RBC flow-speed information. Simulations of 250 tissue-like models including up to 2000 individual blood vessels were used to evaluate the method. The absolute root mean square (RMS) deviation between estimated and true oxygenation was 4.1 percentage units, whereas the relative RMS deviations for the RBC tissue fraction and perfusion were 19% and 23%, respectively. Examples of in vivo measurements on forearm and foot during common provocations are presented. The method offers several advantages such as simultaneous quantification of RBC tissue fraction and oxygenation and perfusion from the same, predict...Continue Reading

Citations

May 10, 2017·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Hanna JonassonTomas Strömberg
Dec 23, 2016·Journal of Biomedical Optics·Ingemar Fredriksson, Marcus Larsson
Nov 16, 2017·Journal of Biomedical Optics·Ingemar FredrikssonTomas Strömberg
Oct 12, 2017·Journal of Biomedical Optics·Ingemar Fredriksson, Marcus Larsson
Jan 25, 2019·Journal of Biomedical Optics·Ingemar FredrikssonMarcus Larsson
Sep 13, 2019·Journal of Biomedical Optics·Hanna JonassonTomas Strömberg
Mar 7, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Hanna JonassonTomas Strömberg
Oct 6, 2020·Biomedical Optics Express·Asgeir Bjorgan, Lise Lyngsnes Randeberg
Oct 19, 2017·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Sara BergstrandTomas Strömberg
Nov 11, 2021·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Ingemar FredrikssonFredrik Iredahl

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