Inverse Monte Carlo method in a multilayered tissue model for diffuse reflectance spectroscopy

Journal of Biomedical Optics
Ingemar FredrikssonTomas Strömberg

Abstract

Model based data analysis of diffuse reflectance spectroscopy data enables the estimation of optical and structural tissue parameters. The aim of this study was to present an inverse Monte Carlo method based on spectra from two source-detector distances (0.4 and 1.2 mm), using a multilayered tissue model. The tissue model variables include geometrical properties, light scattering properties, tissue chromophores such as melanin and hemoglobin, oxygen saturation and average vessel diameter. The method utilizes a small set of presimulated Monte Carlo data for combinations of different levels of epidermal thickness and tissue scattering. The path length distributions in the different layers are stored and the effect of the other parameters is added in the post-processing. The accuracy of the method was evaluated using Monte Carlo simulations of tissue-like models containing discrete blood vessels, evaluating blood tissue fraction and oxygenation. It was also compared to a homogeneous model. The multilayer model performed better than the homogeneous model and all tissue parameters significantly improved spectral fitting. Recorded in vivo spectra were fitted well at both distances, which we previously found was not possible with a ho...Continue Reading

References

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Apr 23, 2002·Journal of Biomedical Optics·Marcus LarssonTomas Strömberg
Mar 5, 2008·Journal of Biomedical Optics·Ingemar FredrikssonTomas Strömberg
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May 13, 2010·Journal of Biomedical Optics·Tobias LindberghTomas Strömberg
Nov 9, 2010·Journal of Biomedical Optics·Ingemar FredrikssonTomas Strömberg
Oct 28, 2011·Journal of Biomedical Optics·Dmitry Yudovsky, Anthony J Durkin

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Citations

Sep 13, 2015·Mathematical Biosciences·Laura VinckenboschTiphaine Obara
Nov 16, 2017·Journal of Biomedical Optics·Ingemar FredrikssonTomas Strömberg
Oct 12, 2017·Journal of Biomedical Optics·Ingemar Fredriksson, Marcus Larsson
Sep 13, 2019·Journal of Biomedical Optics·Hanna JonassonTomas Strömberg
Jun 21, 2012·Optics Express·Hanna KarlssonTomas Strömberg
Feb 5, 2015·Journal of Biomedical Optics·Ricky HennessyJames W Tunnell

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