Inverse Opal Scaffolds with Gradations in Mineral Content for Spatial Control of Osteogenesis

Advanced Materials
Chunlei ZhuYounan Xia

Abstract

The design and fabrication of inverse opal scaffolds with gradations in mineral content to achieve spatial control of osteogenesis are described. The gradient in mineral content is established via the diffusion-limited transport of hydroxyapatite nanoparticles in a closely packed lattice of gelatin microbeads. The mineral-graded scaffold has an array of uniform pores and interconnected windows to facilitate efficient transport of nutrients and metabolic wastes, ensuring high cell viability. The graded distribution of mineral content can provide biochemical and mechanical cues for spatially regulating the osteogenic differentiation of adipose-derived stromal cells. This new class of scaffolds holds promise for engineering the interfaces between mineralized and unmineralized tissues.

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Citations

Aug 24, 2019·Nanoscale·Filipe V FerreiraOrlando J Rojas
Nov 30, 2019·Nanomedicine·Michael J HillMorteza Mahmoudi
Mar 14, 2020·Micromachines·Andrea ChiappiniGiancarlo C Righini
Jul 13, 2020·Biotechnology Journal·Hemant Kumar RautSeeram Ramakrishna
Mar 12, 2021·Advanced Healthcare Materials·Chunlei ZhuYounan Xia
Jun 19, 2019·ACS Biomaterials Science & Engineering·Alexander J BoysLawrence J Bonassar
Aug 22, 2021·Advanced Materials·Marius SchöttleMarkus Retsch
Jan 15, 2021·ACS Applied Materials & Interfaces·Wanqing WengYuanjin Zhao
Nov 27, 2018·Acta Biomaterialia·Yunlang CaiYuanjin Zhao

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