Inverse optimization of low-cost kilovoltage x-ray arc therapy plans

Medical Physics
Dylan Y BreitkreutzMagdalena Bazalova-Carter

Abstract

The objective of this work was to investigate the benefits of using inverse optimization treatment planning for kilovoltage arc therapy (KVAT) and to assess the dosimetric limitations of KVAT. Monte Carlo (MC) calculated, inversely optimized KVAT plans of spherical, idealized breast, lung, and prostate lesions were calculated using the EGSnrc/BEAMnrc and DOSXYZnrc MC codes. The dose delivered with the KVAT system, which generates 200-225 kV photon beamlets, was calculated and inversely optimized using an optimization framework developed at McGill University. KVAT dose distributions were compared with inversely optimized and MC generated megavoltage (MV) volumetric modulated arc therapy (VMAT) plans as a reference. Prescription doses delivered to 95% of the planning target volume (PTV) were 38.5 (10 fractions), 60 (30 fractions) and 73.8 (41 fractions) Gy for the breast, lung and prostate patients, respectively. Dose distributions, dose volume histograms, and PTV homogeneity indices were used to evaluate KVAT and VMAT plans based on RTOG protocols. All organ-at-risk (OAR) doses were within prescribed dose limits for KVAT and VMAT plans. Generally, KVAT plans delivered higher doses to OARs. For example, due to the lower energy of...Continue Reading

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Citations

Nov 1, 2019·Biomedical Physics & Engineering Express·Dylan Yamabe BreitkreutzMagdalena Bazalova-Carter
Aug 15, 2021·Medical Physics·Tyler StalbaumDouglas Boyd

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