Abstract
We present a particle swarm optimization (PSO)-based technique to create deliverable four-dimensional (4D = 3D + time) intensity-modulated radiation therapy (IMRT) plans for lung stereotactic body radiotherapy (SBRT). The 4D planning concept uses respiratory motion as an additional degree of freedom to achieve further sparing of organs at risk (OARs). The 4D-IMRT plan involves the delivery of an order of magnitude more IMRT apertures (~15,000-20,000), with potentially large interaperture variations in the delivered fluence, compared to conventional (i.e., 3D) IMRT. In order to deliver the 4D plan in an efficient manner, we present an optimization-based aperture sequencing technique. A graphic processing unit (GPU)-enabled PSO-based inverse planning engine, developed and integrated with a research version of the Eclipse (Varian, Palo Alto, CA) treatment planning system (TPS), was employed to create 4D-IMRT plans as follows. Four-dimensional computed tomography scans (4DCTs) and beam configurations from clinical treatment plans of seven lung cancer patients were retrospectively collected, and in each case, the PSO engine iteratively adjusted aperture monitor unit (MU) weights for all beam apertures across all respiratory phases t...Continue Reading
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