Inverse-planned modulated-arc total-body irradiation

Medical Physics
Neil KirbyJ Pouliot

Abstract

To develop a simple and robust method for inverse-planned total-body irradiation (TBI) that is more comfortable and has better dose homogeneity than the conventional forward-planned techniques and that can be delivered in a standard-sized treatment vault. Modulated-arc TBI (MATBI) utilizes an arc of static open-field beams to irradiate patients as they lay on a stationary couch beneath the gantry, with cerrobend blocks suspended over organs at risk to provide shielding. Prior to treatment, full-body computed tomography (CT) images are acquired of each patient and imported into the PINNACLE(3) planning system, which modulates the monitor units for the open-field beams to optimize the body dose uniformity. The volume of the body within 10% of the prescription dose, V(±10), is used as a metric to evaluate the dose uniformity. For comparison to MATBI, the dose distribution of a conventional forward-planned treatment is also calculated. Quality assurance measurements are acquired before treatment by delivering the plans to a phantom and during treatment with an ionization chamber inside a buildup block, placed between the patient's ankles. For MATBI, the achieved values of V(±10) were 75.8%, 90.2%, 84.6%, and 79.8% compared to 60.3%...Continue Reading

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Citations

Aug 17, 2012·Medical Physics·Mareike HeldJean Pouliot
Aug 21, 2013·BioMed Research International·Ho-Hsing ChenJin-Ching Lin
Aug 16, 2015·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Martin PolednikFrederik Wenz
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Jun 4, 2014·Journal of Applied Clinical Medical Physics·Roumiana Chakarova, Marcus Krantz
Nov 7, 2019·Journal of Medical Radiation Sciences·Beth EffeneyAndrew Pullar
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Jul 15, 2021·Journal of Applied Clinical Medical Physics·León G AldrovandiMaría L Mairal
Aug 26, 2021·Journal of Applied Clinical Medical Physics·Madison NaessigNeil Kirby

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