PMID: 8602596Mar 1, 1996Paper

Inverse relation between the concentration of low-density-lipoprotein vitamin E and severity of coronary artery disease

The American Journal of Clinical Nutrition
J RegnströmA Hamsten

Abstract

Oxidation of low-density lipoprotein (LDL) is believed to play an important role in atherogenesis, and antioxidant vitamins are thought to protect against coronary artery disease (CAD). We investigated whether the vitamin E concentrations in serum and LDL were associated with the severity of CAD as assessed by a semiquantitative scoring system in which coronary angiograms are analyzed for the number and size of distinct stenotic lesions (global stenosis score). The study group consisted of 64 consecutive male survivors of myocardial infarction aged < 45 y. Lipid-adjusted serum and LDL vitamin E concentrations were significantly lower in the patients than in 35 age-matched male control subjects, whereas the absolute serum and LDL vitamin E concentrations did not differ significantly. No associations were found between the serum concentration or lipid-adjusted serum values of vitamin E and the stenosis score. In contrast, significant inverse correlation was found between the LDL vitamin E concentration, whether adjusted to the lipid (r=-0.477,P<0.001) or protein (r=-0.375, P<0.01) content of LDL, and the global coronary stenosis score. We conclude that a low LDL vitamin E concentration might play a role in the development of sten...Continue Reading

Citations

Mar 4, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·L P van de VijverH M Princen
Aug 31, 1999·The Proceedings of the Nutrition Society·P A Morrissey, P J Sheehy
Oct 8, 1999·Journal of the American College of Nutrition·J W AndersonP R Oeltgen
Mar 12, 1998·Journal of Cardiopulmonary Rehabilitation·T R ThomasT LaFontaine
Jul 27, 2001·The American Journal of Clinical Nutrition·K HayesD Perlman
Apr 1, 1997·Journal of Clinical Pathology·A F Winder
Jul 9, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Anatol KontushRoland Stocker
May 15, 2001·Journal of the American College of Nutrition·B HennigC J McClain
Nov 14, 1997·Nutrition Reviews·H J Palmer, K E Paulson
Oct 15, 1998·The Journal of Nutrition·A C Chan
May 13, 2003·The Proceedings of the Nutrition Society·James W Anderson
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Mar 5, 2011·European Journal of Pharmacology·Vladimir A KostyukLiudmila G Korkina

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