Inverse relation of exchangeable sodium and blood pressure in hypertensive patients with renal artery stenosis

Journal of Hypertension
D McAreaveyJ I Robertson

Abstract

Measurements of exchangeable sodium, arterial pressure and plasma concentrations of active renin, angiotensin II, aldosterone, sodium and potassium were made in 35 hypertensive patients with renal artery stenosis, 30 having unilateral renal arterial lesions. Plasma urea was below 7 mmol/l in 24 of the patients with unilateral lesions. In these and in the whole group of 35 patients there were significant inverse correlations between exchangeable sodium and diastolic blood pressure and between plasma sodium concentration and diastolic pressure. Six patients had hyponatraemia with a plasma sodium concentration less than 135 mmol/l. All were sodium-deplete with secondary hyperaldosteronism, three also having malignant-phase hypertension. Twelve of the patients with unilateral renal artery stenosis underwent bilateral ureteric catheterization. Sodium excretion was greater from the contralateral kidney than from the affected kidney and the rate of sodium excretion from the former, but not from the latter, was significantly related to arterial pressure. The relation of diastolic blood pressure and exchangeable sodium is the opposite of the positive correlation found in essential hypertension and Conn's syndrome. In renal artery stenos...Continue Reading

Citations

Mar 1, 1990·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·T E Bunchman, A R Sinaiko
Jun 15, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·M Gary Nicholls
Jan 1, 1990·Clinical and Experimental Hypertension. Part A, Theory and Practice·H E EliahouA Blau
Oct 1, 1987·Kidney International·J I Robertson
Feb 1, 2003·Journal of Evaluation in Clinical Practice·J Ian S Robertson
Jan 1, 1987·Clinical and Experimental Hypertension. Part A, Theory and Practice·M G Nicholls
Feb 1, 2012·Clinical Kidney Journal·Unnikrishnan PillaiKalyani Mehta

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