Inverse relationship between HIV-1 p24 antigenemia, anti-p24 antibody and neutralizing antibody response in all stages of HIV-1 infection

Immunology Letters
Y SeiJ G Bekesi

Abstract

A double blind cohort study was conducted on 149 homosexual males and 36 patients with AIDS to investigate the relationship between HIV-1 antigenemia, the presence of neutralizing antibody (NA) activity and specific anti-viral core protein (p24) antibody (Ab) in the sera of HIV infected individuals during their progression to AIDS. All AIDS patients and 68% (101/149) of the homosexual males were HIV seropositive upon entering the study. Of those 48 (32%) homosexuals who were HIV negative at the onset, three seroconverted during the two year observation period. Retrospective studies of the HIV(-) subjects' sequentially stored serum samples demonstrated an early transient appearance of gag encoded p24 antigen (Ag) which preceded their production of NA and specific anti-p24 Ab. Following their seroconversion, no more circulating p24 Ag could be detected. Among the 101 HIV positive homosexuals, 16% rapidly progressed to AIDS and seven of these 16 (44%) subjects eventually died during the two year observation period. In this group of individuals with poor prognosis, presence of NA and anti-p24 Ab commenced at the onset reaching peak levels just prior to developing AIDS and began to decline as the clinical course worsened. Their circ...Continue Reading

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Apr 1, 1986·The Journal of Infectious Diseases·J E GroopmanS Landesman
Jul 9, 1987·The New England Journal of Medicine·E J HoltzmanU Goldbourt
Nov 15, 1984·The New England Journal of Medicine·J LaurenceL Montagnier
Oct 10, 1986·Science·G W Barlow

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Citations

May 1, 1993·Journal of Clinical Immunology·M B VasudevachariH C Lane
Oct 1, 1990·Journal of Virological Methods·J PovolotskyD Armstrong
Jan 20, 1998·Journal of Immunological Methods·D O PalenzuelaO Ganzó
May 16, 2014·Archives of Microbiology·Mariam Gamkrelidze, Krystyna Dąbrowska
Dec 10, 2009·International Journal of Toxicology·Aaron B CowleyHarmeet Sidhu
Mar 1, 1993·Microbiological Reviews·J A Levy

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