Inverse relationship between serum high density lipoprotein and negative syndrome in antipsychotic-naive schizophrenia

Clinical Chemistry and Laboratory Medicine : CCLM
Ganesan VenkatasubramanianBangalore N Gangadhar

Abstract

Recent literature suggests a role for apolipoprotein L (apoL) aberrations in the pathogenesis of schizophrenia. ApoL is almost exclusively associated with apolipoprotein A-I in high-density lipoproteins (HDLs). The objective of this study was to examine the correlation between symptom scores and serum HDL in antipsychotic-naive schizophrenia patients. In this cross-sectional study, 60 antipsychotic-naive schizophrenia patients were systematically examined for their symptom scores, with good inter-rater reliability. Concurrently, an overnight fasting serum lipid profile from these patients was assessed. Serum HDL had a significant inverse correlation with a total negative syndrome score (rho=-0.43; p=0.001). The study observation supports the potential role for HDL abnormalities in the genesis of negative symptoms in schizophrenia.

References

Oct 9, 1995·American Journal of Medical Genetics·S G SchwabM Ackenheil
May 13, 1998·Prostaglandins, Leukotrienes, and Essential Fatty Acids·F M CorriganG Cousland
Sep 2, 1999·Prostaglandins, Leukotrienes, and Essential Fatty Acids·D F Horrobin
Mar 27, 2001·Current Opinion in Lipidology·J M Dietschy, S D Turley
Jun 13, 2002·The Australian and New Zealand Journal of Psychiatry·Gregor E BergerPatrick D McGorry
Nov 14, 2002·Molecular Neurobiology·J Gregor Sutcliffe, Elizabeth A Thomas
Oct 29, 2003·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Sakae TakahashiTakuya Kojima
Oct 27, 2004·Annals of Neurology·Henrike WolfHermann-Josef Gertz
Jun 15, 2007·Child and Adolescent Psychiatric Clinics of North America·Doron Gothelf
Sep 28, 2007·The American Journal of Psychiatry·Ganesan VenkatasubramanianK Taranath Shetty

❮ Previous
Next ❯

Citations

May 10, 2012·FEBS Letters·Chien-An A HuPatricio E Ray
Jul 19, 2019·Heliyon·Anastasiia S BoikoSvetlana A Ivanova

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here