PMID: 3768391Nov 14, 1986Paper

Inverse relationship of ethane or n-pentane and malondialdehyde formed during lipid peroxidation in rat liver microsomes with different oxygen concentrations

Biochimica Et Biophysica Acta
J Kostrucha, H Kappus

Abstract

When we incubated rat liver microsomes with ferrous ions and an NADPH-regenerating system, ethane and n-pentane formation increased correspondingly with decreasing concentrations of oxygen in the atmosphere above the incubation, whereas malondialdehyde increased with increasing oxygen concentrations up to a plateau. At very low oxygen concentrations - 100% helium as atmosphere, but presumably traces of oxygen were present in the microsomes - ethane and n-pentane formation were maximal and dependent on the concentrations of ferrous ions, in the case of ethane, a peak being reached at about 20 microM Fe2+, whereas n-pentane continuously increased with increasing concentrations of Fe2+. It is suggested that the inverse relationship of ethane or n-pentane and malondialdehyde is due to two different reaction sequences of microsomal lipid peroxidation with different oxygen sensitivities.

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Citations

Jan 1, 1989·Free Radical Biology & Medicine·W A Pryor
Jan 1, 1989·Free Radical Biology & Medicine·S PuntaruloA I Cederbaum
Jan 1, 1991·Free Radical Biology & Medicine·S R Thom, M E Elbuken
Aug 1, 1994·Free Radical Biology & Medicine·C M KneepkensC C Roy
Jul 25, 1997·Clinica Chimica Acta; International Journal of Clinical Chemistry·J A DruryR W Cooke
Apr 28, 2001·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·M N Loiseaux-MeunierD Caillaud
Jan 1, 1997·Free Radical Biology & Medicine·J A DruryR W Cooke
Jun 1, 1992·Acta Physiologica Scandinavica·M AhotupaH Toivonen
Sep 1, 1990·Toxicology and Applied Pharmacology·S R Thom
Apr 1, 1989·Biochemical Pharmacology·R F Burk, T M Ludden
Sep 1, 1992·Scandinavian Journal of Clinical and Laboratory Investigation·O M Pitkänen
Jul 1, 1994·Acta Paediatrica·E VarsilaS Andersson
Mar 4, 1988·Biochimica Et Biophysica Acta·U P Steinbrecher

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