PMID: 7526888Nov 1, 1994Paper

Inverse relationships between cell proliferation and basal or androgen-stimulated apolipoprotein D secretion in LNCaP human prostate cancer cells

The Journal of Steroid Biochemistry and Molecular Biology
K SugimotoF Labrie

Abstract

We have recently demonstrated that the biphasic action of androgens on LNCaP cell proliferation is opposite to their effect on apolipoprotein D (apo-D) secretion, the stimulation of apo-D secretion being associated with a steroid-induced inhibition of cell proliferation. To further characterize the control of apo-D expression in LNCaP cells, we studied basal as well as androgen-induced apo-D secretion in slowly proliferating, low-passage (LP; 20-29th) and rapidly proliferating high-passage (HP; 111-117th) cell cultures. For comparison, the androgen-induced stimulation of prostate specific antigen secretion was also investigated in LP and HP cell cultures. In the absence of androgens, basal cell proliferation of HP cells was significantly higher than that of LP cells, whereas apo-D secretion was higher in LP cells than in HP cells. Furthermore, the biphasic action of dihydrotestosterone and of the synthetic androgenic compound R1881 on apo-D release and cell proliferation was observed in both LP and HP cells. The stimulation of apo-D secretion was inversely related to that of cell proliferation and influenced by cell density. The inhibition of basal and androgen-induced cell proliferation by the calcium channel blocker nifedipin...Continue Reading

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Citations

Feb 1, 1996·The Journal of Steroid Biochemistry and Molecular Biology·C GuillemetteA Bélanger
Mar 10, 1997·Journal of Immunological Methods·G KnippingE Malle
Mar 24, 1998·Molecular and Cellular Endocrinology·M EsquenetG Verhoeven
Sep 3, 2009·Reproductive Biology and Endocrinology : RB&E·Sonia Do CarmoEric Rassart
Jun 20, 2007·Genome Biology·Daniella Bianchi-FriasPeter S Nelson
Sep 12, 2013·PloS One·Ole AmmerpohlPaul-Martin Holterhus
Feb 5, 2016·Biochimica Et Biophysica Acta·Jasmina PaluncicDes R Richardson
Jul 26, 2008·Experimental Eye Research·Vanessa SeamonAna Maria Azzarolo
May 5, 2007·Biochimica Et Biophysica Acta·Sonia Do CarmoEric Rassart
Mar 10, 2015·Frontiers in Pharmacology·Eva Martínez-PinillaRafael Franco
Dec 17, 2014·PloS One·Sten Braesch-AndersenMakiko Kumagai-Braesch
Mar 28, 2012·The Journal of Steroid Biochemistry and Molecular Biology·Sylvain GauthierFernand Labrie
Aug 2, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Stephen B HunterChin-Yih Ou
Jan 13, 2004·The Prostate·R E HallWayne D Tilley
May 29, 2003·Journal of Surgical Oncology·Eva MirandaAntonio Martínez Merino
Jan 31, 2003·The Journal of Biological Chemistry·Thierry VirolleDan Mercola
Jan 3, 2013·The Prostate·Michael A PochHannelore V Heemers
Nov 13, 2008·The Journal of Biological Chemistry·Yasushi SasakiTakashi Tokino
Oct 26, 2021·Frontiers in Physiology·Diego Sanchez, Maria D Ganfornina

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