Inverse sex-based expression profiles of PTEN and Klotho in mice

Scientific Reports
Natalia Prudente de MelloElisa Mitiko Kawamoto

Abstract

Sex differences are considered predictive factors in the development of several neurological diseases, which are also known to coincide with impaired phosphoinositide 3-kinase (PI3K)-AKT pathway activity, an essential signaling cascade involved in the control of several cellular functions such as autophagy and apoptosis. Here, under physiological conditions, we show important sex differences in the underlying balancing mechanisms that lead to similar AKT activity levels and autophagy and apoptosis processes in the two sexes. We demonstrate inverse sex-based expression of PTEN and Klotho, two important proteins that are known to negatively regulate the AKT pathway, and inverse sex-dependent levels of mTOR and FoxO3a activity. Taken together, our findings indicate that inverse sex-based regulation may be one of the underlying balancing mechanisms that differ between the sexes and a possible cause of sex-based autophagic and apoptotic responses to triggering situations that can lead to a sex-based predisposition to some neurological diseases.

References

Mar 18, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·G F WootenJ Patrie
Nov 14, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·Charlotte A HaaxmaMartin W I M Horstink
Jul 20, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·K S M TaylorC E Counsell
Aug 24, 2012·Journal of Clinical and Experimental Neuropsychology·Karen IrvineTejinder K Kondel
Apr 11, 2013·Sexual Development : Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation·L McFarlaneD Wilhelm
May 11, 2013·Cell Death & Disease·P Sanphui, S C Biswas
Nov 12, 2013·Neuroscience Letters·Richard D SembaRichard O'Brien
Nov 12, 2013·Progress in Neurobiology·Saeid GhavamiMarek J Łos
May 15, 2015·Molecular Autism·Christine Wu NordahlDavid G Amaral
Nov 6, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Dario CupolilloDaniela Carulli
Dec 24, 2015·Aging Cell·Emma L BaarDudley W Lamming
Dec 25, 2015·Journal of Neurology, Neurosurgery, and Psychiatry·Frédéric MoisanAlexis Elbaz
Jan 19, 2016·Nature Neuroscience·Shira KnafoJosé A Esteban
Dec 28, 2016·Journal of Molecular Neuroscience : MN·Long WangXuming Mo
Jul 6, 2019·Frontiers in Neuroscience·Sami GabboujTeemu Natunen
Jul 17, 2019·Cold Spring Harbor Perspectives in Medicine·Thomas W Frazier
Apr 15, 2020·NPJ Parkinson's Disease·Tyler Harrison ReekesElizabeth Ann Disbrow
Feb 13, 2021·NPJ Parkinson's Disease·Tyler Harrison ReekesElizabeth Ann Disbrow

❮ Previous
Next ❯

Citations

Jun 9, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Vignesh ChidambaramPetros C Karakousis

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
dissection
electrophoresis
PCR

Software Mentioned

GraphPad
ImageJ
GraphPad Prism

Related Concepts

Related Feeds

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Journal of Women's Health & Gender-based Medicine
Phyllis Greenberger
The Journal of Clinical Hypertension
Jamario SkeeteDonald J DiPette
European Journal of Preventive Cardiology
Nathalia Gonzalez-JaramilloArjola Bano
© 2021 Meta ULC. All rights reserved