Inverse Thermogelation of Aqueous Triblock Copolymer Solutions into Macroporous Shear-Thinning 3D Printable Inks

ACS Applied Materials & Interfaces
Lukas HahnRobert Luxenhofer

Abstract

Amphiphilic block copolymers that undergo (reversible) physical gelation in aqueous media are of great interest in different areas including drug delivery, tissue engineering, regenerative medicine, and biofabrication. We investigated a small library of ABA-type triblock copolymers comprising poly(2-methyl-2-oxazoline) as the hydrophilic shell A and different aromatic poly(2-oxazoline)s and poly(2-oxazine)s cores B in an aqueous solution at different concentrations and temperatures. Interestingly, aqueous solutions of poly(2-methyl-2-oxazoline)-block-poly(2-phenyl-2-oxazine)-block-poly(2-methyl-2-oxazoline) (PMeOx-b-PPheOzi-b-PMeOx) undergo inverse thermogelation below a critical temperature by forming a reversible nanoscale wormlike network. The viscoelastic properties of the resulting gel can be conveniently tailored by the concentration and the polymer composition. Storage moduli of up to 110 kPa could be obtained while the material retains shear-thinning and rapid self-healing properties. We demonstrate three-dimensional (3D) printing of excellently defined and shape-persistent 24-layered scaffolds at different aqueous concentrations to highlight its application potential, e.g., in the research area of biofabrication. A mac...Continue Reading

References

Mar 30, 2010·Biomaterials·Robert LuxenhoferAlexander V Kabanov
Nov 29, 2011·Macromolecular Rapid Communications·Meta M BloksmaRichard Hoogenboom
May 23, 2012·Macromolecular Bioscience·Ning ZhangRainer Jordan
Jul 5, 2012·Macromolecular Rapid Communications·Brieuc GuillermJean-Jacques Robin
Sep 22, 2012·Macromolecular Rapid Communications·Rupert KonradiMarcus Textor
Jul 25, 2013·Chemical Society Reviews·Patrick TheatoThomas H Epps
Jul 21, 2016·Scientific Reports·Yong HeJianZhong Fu
Oct 25, 2016·Angewandte Chemie·Giulia MorgeseEdmondo M Benetti
Nov 30, 2016·International Journal of Molecular Sciences·Eneko Axpe, Michelle L Oyen
Jun 28, 2017·Biomacromolecules·Thomas LorsonRobert Luxenhofer
Jul 28, 2017·Journal of the American Chemical Society·Michael M LübtowRobert Luxenhofer
Mar 21, 2018·Materials·Ahasan HabibBashir Khoda
Jun 27, 2018·Biomaterials·Thomas LorsonRobert Luxenhofer
Jan 25, 2019·Gels·Coro EcheverriaPaula I P Soares
Jul 11, 2019·Chemistry : a European Journal·Michael M LübtowRobert Luxenhofer
May 14, 2008·Soft Matter·Suk-Kyun AhnYuxiang Zhou
Oct 10, 2016·ACS Biomaterials Science & Engineering·Lokesh Karthik NarayananRohan A Shirwaiker

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Citations

Oct 2, 2020·Advanced Science·Zhen JiangLuke A Connal
Jan 16, 2021·Advanced Healthcare Materials·Anna Zahoranová, Robert Luxenhofer
Mar 18, 2021·Biomaterials Science·Lucca TrachselEdmondo M Benetti
May 27, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chen HuRobert Luxenhofer
Jun 9, 2021·Biomacromolecules·Lukas HahnRobert Luxenhofer

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