Invertebrate 7SK snRNAs

Journal of Molecular Evolution
Andreas R GruberBernd-Joachim Benecke

Abstract

7SK RNA is a highly abundant noncoding RNA in mammalian cells whose function in transcriptional regulation has only recently been elucidated. Despite its highly conserved sequence throughout vertebrates, all attempts to discover 7SK RNA homologues in invertebrate species have failed so far. Here we report on a combined experimental and computational survey that succeeded in discovering 7SK RNAs in most of the major deuterostome clades and in two protostome phyla: mollusks and annelids. Despite major efforts, no candidates were found in any of the many available ecdysozoan genomes, however. The additional sequence data confirm the evolutionary conservation and hence functional importance of the previously described 3' and 5' stem-loop motifs, and provide evidence for a third, structurally well-conserved domain.

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Citations

Sep 26, 2009·Briefings in Functional Genomics & Proteomics·Axel MosigPeter F Stadler
Sep 8, 2009·Molecular Biology and Evolution·Manja MarzOlivier Bensaude
Jan 20, 2009·Nucleic Acids Research·Jana HertelPeter F Stadler
Nov 23, 2010·Nucleic Acids Research·Sebastian EilebrechtArndt Benecke
Aug 3, 2010·Nucleic Acids Research·Isabelle LebarsAnne-Catherine Dock-Bregeon
Mar 21, 2009·RNA·Cécile Bousquet-Antonelli, Jean-Marc Deragon
Oct 29, 2009·RNA·Peter MenzelPeter F Stadler
Oct 9, 2012·Biochimica Et Biophysica Acta·Giorgio DieciDavide Carnevali
Aug 20, 2011·Wiley Interdisciplinary Reviews. RNA·B Matija PeterlinDavid H Price
Apr 12, 2015·Biochimie·Denise Martinez-ZapienAnne-Catherine Dock-Bregeon
Feb 26, 2009·Cell·Chris P PontingWolf Reik
Jun 23, 2016·Nucleic Acids Research·Florian EggenhoferChristian Höner Zu Siederdissen
Sep 30, 2016·Nucleic Acids Research·Catherine D EichhornJuli Feigon
Feb 26, 2010·Journal of Bioinformatics and Computational Biology·Manja MarzPeter F Stadler
Dec 9, 2017·RNA Biology·Ali M YazbeckPeter F Stadler
Nov 17, 2019·Nucleic Acids Research·Konstantin RöderSamuela Pasquali
Jun 19, 2015·Molecular Genetics and Genomics : MGG·Bin LiuKuo-Chen Chou
Jan 14, 2017·Nucleic Acids Research·Denise Martinez-ZapienAnne-Catherine Dock-Bregeon
Sep 1, 2021·BMC Molecular and Cell Biology·Duy NguyenPatricia Uguen

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Methods Mentioned

BETA
PCR

Software Mentioned

RALEE

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