Invertebrate hematopoiesis: an anterior proliferation center as a link between the hematopoietic tissue and the brain

Stem Cells and Development
Chadanat NooninIrene Söderhäll

Abstract

During evolution, the innate and adaptive immune systems were developed to protect organisms from non-self substances. The innate immune system is phylogenetically more ancient and is present in most multicellular organisms, whereas adaptive responses are restricted to vertebrates. Arthropods lack the blood cells of the lymphoid lineage and oxygen-carrying erythrocytes, making them suitable model animals for studying the regulation of the blood cells of the innate immune system. Many crustaceans have a long life span and need to continuously synthesize blood cells, in contrast to many insects. The hematopoietic tissue (HPT) of Pacifastacus leniusculus provides a simple model for studying hematopoiesis, because the tissue can be isolated, and the proliferation of stem cells and their differentiation can be studied both in vivo and in vitro. Here, we demonstrate new findings of a physical link between the HPT and the brain. Actively proliferating cells were localized to an anterior proliferation center (APC) in the anterior part of the tissue near the area linking the HPT to the brain, whereas more differentiated cells were detected in the posterior part. The central areas of HPT expand in response to lipopolysaccharide-induced b...Continue Reading

References

Apr 19, 2002·Chronobiology International·Rune SmaalandJenny Foss Abrahamsen
Mar 22, 2003·Current Opinion in Cell Biology·Toren Finkel
May 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Irene SöderhällKenneth Söderhäll
May 26, 2006·Nature Reviews. Molecular Cell Biology·Eran Meshorer, Tom Misteli
Oct 20, 2007·Nature Reviews. Immunology·Dominique FerrandonJules A Hoffmann
Feb 21, 2008·Nature Reviews. Molecular Cell Biology·M Celeste Simon, Brian Keith
May 7, 2008·Trends in Immunology·Lage CereniusKenneth Söderhäll
Jul 24, 2008·The FEBS Journal·Justin Monnier, Michel Samson
Jul 18, 2009·International Review of Neurobiology·Lucia NegriPietro Melchiorri
Mar 31, 2010·Expert Opinion on Therapeutic Targets·Aldo GiudiceClaudio Arra
Jun 15, 2010·Trends in Biochemical Sciences·Lage CereniusKenneth Söderhäll
Jul 2, 2010·The Journal of Biological Chemistry·Xionghui LinIrene Söderhäll
Jul 24, 2010·Cellular and Molecular Life Sciences : CMLS·Apiruck WatthanasurorotIrene Söderhäll
Aug 5, 2010·Cell Stem Cell·Ahmed MohyeldinAlfredo Quiñones-Hinojosa
Aug 17, 2010·Developmental Biology·Joanna KrzemienAlain Vincent
Jan 12, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xionghui LinIrene Söderhäll
Mar 30, 2011·Blood·Xionghui Lin, Irene Söderhäll
Apr 22, 2011·Development Genes and Evolution·Melina GrigorianVolker Hartenstein
Sep 21, 2011·The European Journal of Neuroscience·Barbara S BeltzDavid C Sandeman

❮ Previous
Next ❯

Citations

Jan 16, 2013·Development Genes and Evolution·Melina Grigorian, Volker Hartenstein
Apr 9, 2013·PloS One·Netnapa SaeleeIrene Söderhäll
Jan 2, 2016·Developmental and Comparative Immunology·Irene Söderhäll
Mar 19, 2013·Developmental and Comparative Immunology·Chadanat NooninIrene Söderhäll
Jan 19, 2016·Cytotechnology·Inês Júlia Ribas WajsenzonSilvana Allodi
Jan 8, 2016·Zoology : Analysis of Complex Systems, ZACS·Steffen Harzsch, Oliver von Bohlen Und Halbach
Oct 5, 2014·Developmental and Comparative Immunology·Tewodros Firdissa DuressaRoger Huybrechts
Aug 15, 2014·Developmental Cell·Jeanne L BentonBarbara S Beltz
Nov 5, 2013·Developmental and Comparative Immunology·Lucia Kuhn-NentwigJohann Schaller
Dec 12, 2012·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Jeanne L BentonBarbara S Beltz
Feb 13, 2016·Developmental and Comparative Immunology·Zhihao JiaLinsheng Song
Mar 30, 2013·Developmental and Comparative Immunology·Erick Garcia-GarciaVictor Mulero
Nov 15, 2018·The Journal of Biological Chemistry·Kingkamon JunkunloIrene Söderhäll
Jan 26, 2020·Cellular and Molecular Neurobiology·Paula Grazielle Chaves da SilvaSilvana Allodi
Jun 25, 2016·The Journal of Biological Chemistry·Kingkamon JunkunloChadanat Noonin
Mar 30, 2020·Developmental and Comparative Immunology·Ratchanok SirikharinIrene Söderhäll
Apr 16, 2021·Developmental and Comparative Immunology·Lage Cerenius, Kenneth Söderhäll
Nov 28, 2018·Developmental and Comparative Immunology·Irene Söderhäll, Kingkamon Junkunlo

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
dissection
light microscopy

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.