Investigate the chronic neurotoxic effects of diquat.

Neurochemical Research
Senthilkumar S KaruppagounderMuralikrishanan Dhanasekaran

Abstract

Chronic exposure to agricultural chemicals (pesticides/herbicides) has been shown to induce neurotoxic effects or results in accumulation of various toxic metabolic by-products. These substances have the relevant ability to cause or increase the risk for neurodegeneration. Diquat is an herbicide that has been extensively used in the United States of America and other parts of the world. Diquat is constantly released into the environment during its use as a contact herbicide. Diquat structurally resembles 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP) and paraquat. Rotenone, paraquat, maneb and MPTP reproduce features of movement disorders in experimental animal models. Based on the structural similarity to other neurotoxins, chronic exposure of diquat can induce behavioral and neurochemical alterations associated with dopaminergic neurotoxicity. However, in the present study, diquat unlike other neurotoxins (rotenone, 6-hydroxydopamine, MPTP, paraquat and maneb) did not induce dopamine depletion in the mouse striatum. Although, notable exacerbation in motor impairment (swimming score, akinesia and open field) were evident that may be due to the decreased dopamine turnover and mild nigrostriatal neurodegeneration. These dat...Continue Reading

References

Dec 16, 1992·Journal of the National Cancer Institute·H I MorrisonD Wigle
Jan 1, 1992·Neurology·G P SechiG Rosati
Jan 1, 1990·American Journal of Industrial Medicine·C HertzmanD Calne
Mar 29, 1994·Biochemical Pharmacology·J M RawlingsJ R Heylings
Jan 11, 1996·The New England Journal of Medicine·D A BennettD A Evans
Aug 1, 1995·Brain and Cognition·M E CornfordB L Miller
Jul 18, 1997·Journal of Neuroscience Methods·K KlapdorF J Van der Staay
Jul 10, 1998·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D Muralikrishnan, K P Mohanakumar
Oct 8, 1998·The New England Journal of Medicine·A E Lang, A M Lozano
Apr 15, 1999·Annual Review of Neuroscience·C W Olanow, W G Tatton
May 7, 1999·Epidemiology·H Checkoway, L M Nelson
Aug 12, 1999·Nitric Oxide : Biology and Chemistry·M V Beligni, L Lamattina
Apr 25, 2000·Journal of Toxicology. Clinical Toxicology·G M Jones, J A Vale
May 2, 2001·Nature Reviews. Neuroscience·M F Beal
Mar 16, 2002·Toxicological Sciences : an Official Journal of the Society of Toxicology·Wherly P HoffmanRobert B L van Lier
Aug 30, 2002·Neurochemical Research·Dhanasekaran MuralikrishnanHolly M Brown-Borg
May 2, 2003·Journal of Neuropathology and Experimental Neurology·Takashi IshizawaDennis W Dickson
May 26, 2004·Pharmacology, Biochemistry, and Behavior·Rumiko KurosakiTsutomu Araki
Jun 17, 2004·Environmental Health Perspectives·Freya Kamel, Jane A Hoppin
Oct 27, 2004·Cell and Tissue Research·Andreas Schober
Mar 26, 2005·Brain Research. Molecular Brain Research·Dafna Bonneh-BarkayDonato A Di Monte
May 14, 2005·Antioxidants & Redox Signaling·Dafna Bonneh-BarkayDonato A Di Monte
Jun 15, 2005·Annual Review of Biochemistry·Mark R Cookson
Jul 12, 2005·Neurobiology of Aging·María NietoTeresa Gómez-Isla
Feb 24, 2006·Neurochemistry International·Karuppagounder S SaravananKochupurackal P Mohanakumar
May 24, 2006·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Marinah M Ariffin, Robert A Anderson
Jul 4, 2006·Neurotoxicology·R J Dinis-OliveiraF Carvalho
Aug 18, 2006·Journal of Alzheimer's Disease : JAD·Leigh A HolcombBala V Manyam
Sep 12, 2006·Archives of Environmental & Occupational Health·J Michael Wright, Jane Keller-Byrne
Mar 14, 2007·Journal of Pineal Research·Karuppagounder S SaravananKochupurackal P Mohanakumar
Jul 10, 2007·Bioscience, Biotechnology, and Biochemistry·Masashi HiguchiKiyotaka Watanabe

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Citations

Feb 25, 2014·Life Sciences·Senthilkumar S KaruppagounderMuralikrishnan Dhanasekaran
Mar 10, 2015·Journal of Neural Transmission·Pamela Lopert, Manisha Patel
Dec 20, 2015·Regulatory Toxicology and Pharmacology : RTP·Daniel J MinnemaPhilip A Botham
Dec 31, 2020·Antioxidants·Cadiele Oliana ReichertSergio P Bydlowski
Aug 31, 2021·Frontiers in Veterinary Science·Jiaxin ChenDayou Shi

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