Investigating Antifungal Susceptibility in Candida Species With MALDI-TOF MS-Based Assays

Frontiers in Cellular and Infection Microbiology
Margot DelavyAlix T Coste

Abstract

Half of invasive fungal infections lead to death. Amongst pathogenic fungi, the most widespread species belong to the Candida genus and vary in their susceptibility to antifungal drugs. The emergence of antifungal resistance has become a major clinical problem. Therefore, the definition of susceptibility patterns is crucial for the survival of patients and the monitoring of resistance epidemiology. Although, most routinely used methods of AntiFungal Susceptibility Testing (AFST) have reached their limits, the rediscovery of Matrix Associated Laser Desorption/Ionization Time of Flight Mass Spectrometry (MALDI-TOF MS) in the field of mycology provides a promising alternative for the study of antifungal resistance. MALDI-TOF MS is already used in mycology for fungal identification, which permits to highlight inherent antifungal resistance. However, the main concern of clinicians is the rise of acquired antifungal resistance and the time needed for their detection. For this purpose, MALDI-TOF MS has been shown to be an accurate tool for AFST, presenting numerous advantages in comparison to commonly used techniques. Finally, MALDI-TOF MS could be used directly to detect resistance mechanisms through typing. Consequently, MALDI-TOF M...Continue Reading

References

Nov 28, 2001·Analytical Chemistry·B Amiri-Eliasi, C Fenselau
May 19, 2009·Diagnostic Microbiology and Infectious Disease·Julianna FernandezDavid E Nix
May 25, 2010·Eukaryotic Cell·Anna SelmeckiJudith Berman
Aug 25, 2010·Antimicrobial Agents and Chemotherapy·Claire M MartelSteven L Kelly
Oct 16, 2010·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·O BaderM Kuhns
Feb 16, 2011·Antimicrobial Agents and Chemotherapy·Sélène FerrariDominique Sanglard
Apr 14, 2011·European Journal of Medical Research·C RodloffR Schaumann
Jul 1, 2011·Journal of Clinical Microbiology·Wee Gyo LeeHee-Chang Jang
Nov 3, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·E BilleA Ferroni
Nov 19, 2011·FEMS Microbiology Reviews·Antony CroxattoGilbert Greub
Dec 22, 2011·International Journal of Microbiology·Patrick VandeputteAlix T Coste
Aug 16, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Angela Ahlquist ClevelandTom M Chiller
Dec 21, 2012·Science Translational Medicine·Gordon D BrownTheodore C White
Apr 12, 2013·Expert Review of Proteomics·Brunella PosteraroMaurizio Sanguinetti
Oct 11, 2014·Future Microbiology·Brunella Posteraro, Maurizio Sanguinetti
Jun 3, 2015·Mycoses·Maurizio SanguinettiCornelia Lass-Flörl
Dec 23, 2015·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Eric Delarze, Dominique Sanglard
Jan 26, 2016·Methods : a Companion to Methods in Enzymology·Katrin SparbierMarkus Kostrzewa
Mar 26, 2016·Frontiers in Medicine·Dominique Sanglard
Apr 12, 2016·Mycoses·Carole CassagneRenaud Piarroux
Oct 26, 2016·Antimicrobial Resistance and Infection Control·Silke SchelenzMatthew C Fisher
Nov 25, 2016·Journal of Clinical Microbiology·Masako MizusawaSean X Zhang
Jun 28, 2017·Infection and Drug Resistance·Smita Sarma, Shalini Upadhyay
Nov 17, 2017·Clinical Microbiology Reviews·Anna Jeffery-SmithColin S Brown

❮ Previous
Next ❯

Citations

Apr 24, 2020·Expert Review of Anti-infective Therapy·Ludwig Knabl, Cornelia Lass-Flörl
Apr 17, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Amira ElBaradei
Mar 12, 2021·Journal of Applied Microbiology·P A D F AguiarD V D B Röder
May 1, 2021·International Journal of Molecular Sciences·Lucia ČernákováCélia F Rodrigues
May 22, 2021·Infectious Disease Clinics of North America·Sarah E KiddCatriona L Halliday
May 27, 2021·Studies in Mycology·A ArastehfarM Hoenigl

❮ Previous
Next ❯

Software Mentioned

ASTRA
Bruker
MALDI Biotyper®
MBT

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Journal of Fungi
Maurizio Sanguinetti, Brunella Posteraro
Clinics in Chest Medicine
Nancy L Wengenack, Matthew J Binnicker
Enfermedades infecciosas y microbiología clínica
Juan Luis Rodríguez-TudelaManuel Cuenca-Estrella
© 2022 Meta ULC. All rights reserved