Investigating asthma heterogeneity through shared and distinct genetics: Insights from genome-wide cross-trait analysis.

The Journal of Allergy and Clinical Immunology
Zhaozhong ZhuLiming Liang

Abstract

Asthma is a heterogeneous respiratory disease reflecting distinct pathobiologic mechanisms. These mechanisms are based, at least partly, on different genetic factors shared by many other conditions, such as allergic diseases and obesity. Investigating the shared genetic effects enables better understanding of the mechanisms of phenotypic correlations and is less subject to confounding by environmental factors. The increasing availability of large-scale genome-wide association study (GWAS) for asthma has enabled researchers to examine the genetic contributions to the epidemiologic associations between asthma subtypes and those between coexisting diseases and/or traits and asthma. Studies have found not only shared but also distinct genetic components between asthma subtypes, indicating that the heterogeneity is related to distinct genetics. This review summarizes a recently compiled analytic approach-genome-wide cross-trait analysis-to determine shared and distinct genetic architecture. The genome-wide cross-trait analysis features in several analytic aspects: genetic correlation, cross-trait meta-analysis, Mendelian randomization, polygenic risk score, and functional analysis. In this article, we discuss in detail the scientifi...Continue Reading

References

Nov 26, 1999·Archives of Internal Medicine·C A CamargoF E Speizer
Sep 13, 2000·The Journal of Allergy and Clinical Immunology·G L Larsen
Dec 15, 2000·European Journal of Clinical Investigation·G TonoloM Maioli
Nov 10, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·M Takemoto, J K Liao
Mar 6, 2007·General Hospital Psychiatry·Kate M ScottJosep Maria Haro
May 12, 2007·Brain, Behavior, and Immunity·Edith Chen, Gregory E Miller
Jul 14, 2007·The Journal of Allergy and Clinical Immunology·Roberto J RonaCharlotte Madsen
Aug 7, 2008·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Larry Borish, Jeffrey A Culp
Sep 6, 2008·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Kostas N PriftisEvagelia Lagona
Sep 19, 2008·Nature Immunology·Tracy S P HengUNKNOWN Immunological Genome Project Consortium
Sep 16, 2009·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Padmaja SubbaraoMalcolm R Sears
Oct 9, 2009·Nature·Teri A ManolioPeter M Visscher
Jun 16, 2010·Nature Reviews. Genetics·Alkes L PriceNick Patterson
Aug 25, 2010·American Journal of Respiratory and Critical Care Medicine·Ferenc MacsaliCecilie Svanes
Sep 8, 2010·The Journal of Allergy and Clinical Immunology·Erik MelénJessica Lasky-Su
Sep 24, 2010·The New England Journal of Medicine·Miriam F MoffattUNKNOWN GABRIEL Consortium
Oct 12, 2010·The European Respiratory Journal·E P de GrootP L P Brand
Dec 21, 2010·American Journal of Human Genetics·Jian YangPeter M Visscher
Jun 21, 2011·Immunological Reviews·Carole Ober, Tsung-Chieh Yao
Nov 15, 2011·American Journal of Human Genetics·Shanya SivakumaranHarry Campbell
Mar 3, 2012·PLoS Computational Biology·Purvesh KhatriAtul J Butte
Sep 8, 2012·Nature·UNKNOWN ENCODE Project Consortium
Apr 3, 2013·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Emeka OrakaPaul Garbe
May 30, 2013·Nature Genetics·UNKNOWN GTEx Consortium
Jun 12, 2013·Nature Reviews. Genetics·Nadia SolovieffJordan W Smoller
Jan 17, 2014·The Lancet. Respiratory Medicine·Daniel W BelskyAvshalom Caspi
Dec 17, 2014·American Journal of Human Genetics·Xiaofeng ZhuSusan Redline
Feb 3, 2015·Nature Genetics·Brendan K Bulik-SullivanBenjamin M Neale
Feb 20, 2015·Nature·UNKNOWN Roadmap Epigenomics ConsortiumManolis Kellis
Mar 17, 2015·European Journal of Epidemiology·Stephen BurgessUNKNOWN EPIC- InterAct Consortium
Jun 8, 2015·International Journal of Epidemiology·Jack BowdenStephen Burgess
Sep 29, 2015·Nature Genetics·Brendan Bulik-SullivanBenjamin M Neale
Oct 3, 2015·American Journal of Human Genetics·Bjarni J VilhjálmssonNick Patterson
May 6, 2016·Annual Review of Genomics and Human Genetics·Joshua C DennyDan M Roden
May 18, 2016·Nature Genetics·Joseph K PickrellDavid A Hinds
Oct 19, 2017·International Journal of Epidemiology·Fernando Pires HartwigJack Bowden
Oct 31, 2017·Nature Genetics·Manuel A FerreiraLavinia Paternoster
Jan 3, 2018·Nature Genetics·Patrick TurleyDaniel J Benjamin

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Citations

Nov 27, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Weiqi ZhaiMichael Roth
Apr 30, 2021·Frontiers in Medicine·Yoshihiko RaitaKohei Hasegawa
Sep 13, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Natalie M Diaz-CabreraDennis K Ledford
Sep 23, 2021·PloS One·Cyrielle MaroteauUNKNOWN PiCA Consortium

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Software Mentioned

ASSET
GTEx
ImmGen
CPASSOC

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