Investigating axonal damage in multiple sclerosis by diffusion tensor spectroscopy.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Emily T WoodDaniel S Reich

Abstract

Sensitive and specific in vivo measures of axonal damage, an important determinant of clinical status in multiple sclerosis (MS), might greatly benefit prognostication and therapy assessment. Diffusion tensor spectroscopy (DTS) combines features of diffusion tensor imaging and magnetic resonance spectroscopy, allowing measurement of the diffusion properties of intracellular, cell-type-specific metabolites. As such, it may be sensitive to disruption of tissue microstructure within neurons. In this cross-sectional pilot study, diffusion of the neuronal metabolite N-acetylaspartate (NAA) was measured in the human normal-appearing corpus callosum on a 7 tesla MRI scanner, comparing 15 MS patients and 14 healthy controls. We found that NAA parallel diffusivity is lower in MS (p = 0.030) and inversely correlated with both water parallel diffusivity (p = 0.020) and clinical severity (p = 0.015). Interpreted in the context of previous experiments, our findings provide preliminary evidence that DTS can distinguish axonopathy from other processes such as inflammation, edema, demyelination, and gliosis. By detecting reduced diffusion of NAA parallel to axons in white matter, DTS may thus be capable of distinguishing axonal disruption in M...Continue Reading

References

Dec 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S W Provencher
Feb 1, 1994·Brain : a Journal of Neurology·C A DavieW I McDonald
Sep 1, 1993·Radiology·S PosseD Le Bihan
Jan 29, 1998·The New England Journal of Medicine·B D TrappL Bö
Apr 29, 1998·Brain : a Journal of Neurology·L FuD L Arnold
Jun 9, 1998·IEEE Transactions on Medical Imaging·J G SledA C Evans
Nov 26, 1999·IEEE Transactions on Medical Imaging·D L Pham, J L Prince
Jan 15, 2000·Neurology·O GonenR I Grossman
Oct 12, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R BammerF Fazekas
Jan 23, 2003·Brain : a Journal of Neurology·M FilippiA Falini
Oct 28, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Christopher D KroenkeDmitriy A Yablonskiy
Oct 19, 2005·Brain : a Journal of Neurology·Alexandra KutzelniggHans Lassmann
Dec 13, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jacob EllegoodChristian Beaulieu
Feb 6, 2007·Progress in Neurobiology·John R MoffettAryan M A Namboodiri
Sep 21, 2007·Multiple Sclerosis : Clinical and Laboratory Research·B R SajjaUNKNOWN PROMiSe Trial MRSI Group
Oct 12, 2007·NeuroImage·Jaymin UpadhyayItamar Ronen
Oct 31, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jaymin UpadhyayItamar Ronen
Jun 19, 2008·Annual Review of Neuroscience·Bruce D Trapp, Klaus-Armin Nave
Mar 6, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Matthew D BuddeSheng-Kwei Song
Mar 19, 2009·Brain : a Journal of Neurology·Don J MahadDouglass M Turnbull
Sep 10, 2009·NMR in Biomedicine·Bennett A LandmanPeter C M van Zijl
Feb 10, 2010·Multiple Sclerosis : Clinical and Laboratory Research·A OzturkD S Reich
Mar 11, 2010·Multiple Sclerosis : Clinical and Laboratory Research·Emma C TallantyreNikos Evangelou
Jun 24, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Fredy VisserPeter R Luijten
Jul 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Matthew D Budde, Joseph A Frank
Oct 23, 2010·AJNR. American Journal of Neuroradiology·D J RigottiM Filippi
Nov 12, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Olga CiccarelliAlan J Thompson
Apr 5, 2011·NeuroImage·Aaron CarassJerry L Prince
Nov 16, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Hermien E KanItamar Ronen

❮ Previous
Next ❯

Citations

May 15, 2013·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Linda ChangThomas Ernst
Dec 29, 2013·Trends in Molecular Medicine·Maarten E WitteJack van Horssen
Feb 13, 2013·Multiple Sclerosis International·Serafeim Katsavos, Maria Anagnostouli
Feb 21, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Vaclav BrandejskyRoland Kreis
Feb 4, 2016·Multiple Sclerosis International·Mithu Storoni, Gordon T Plant
Jan 31, 2014·Journal of Magnetic Resonance Imaging : JMRI·Oliver KraffMark E Ladd
Aug 28, 2014·Acta Neuropathologica Communications·Jae LeeSteven Petratos
Jul 6, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ayse Ece ErcanItamar Ronen
Apr 17, 2015·Multiple Sclerosis and Related Disorders·D R AltmannD H Miller
Jul 3, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Massimo FilippiMaria A Rocca
Apr 11, 2017·Multiple Sclerosis : Clinical and Laboratory Research·Benedetta BodiniBruno Stankoff
Jun 22, 2017·Brain : a Journal of Neurology·Ronald ZielmanMark C Kruit
Feb 12, 2020·NMR in Biomedicine·Chris Hanstock, Christian Beaulieu
Aug 31, 2019·Neurology. Neuroimmunology and Neuroinflammation·Kristen R HollingerBarbara S Slusher
Aug 7, 2013·Continuum : Lifelong Learning in Neurology·Eric C Klawiter
Sep 19, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Matthew G StovellKeri Lh Carpenter
Nov 17, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Marco PalomboJulien Valette
Feb 11, 2021·Multiple Sclerosis : Clinical and Laboratory Research·Vito Ag RiciglianoBenedetta Bodini

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.