Investigating causal relationships between sleep traits and risk of breast cancer: a Mendelian randomization study

BioRxiv : the Preprint Server for Biology
Rebecca RichmondGeorge Davey Smith

Abstract

Objective: To examine whether sleep traits have a causal effect on risk of breast cancer. Design: Multivariable regression, one- and two-sample Mendelian randomization. Setting: The UK Biobank prospective cohort study and the Breast Cancer Association Consortium (BCAC) case-control genome-wide association study. Participants: 156,848 women in the multivariable regression and one-sample Mendelian randomization analysis in UK Biobank (7,784 with a breast cancer diagnosis) and 122,977 breast cancer cases and 105,974 controls from BCAC in the two-sample Mendelian randomization analysis. Exposures: Self-reported chronotype (morning/evening preference), insomnia and sleep duration in multivariable regression, and genetic variants that were robustly associated with these exposures in UK Biobank. Main outcome measures: Breast cancer (prevalent and incident cases in UK Biobank, prevalent cases only in BCAC). Results: In multivariable regression analysis using data on breast cancer incidence in the UK Biobank study, morning preference was inversely associated with breast cancer (HR 0.95, 95% CI 0.93, 0.98 per category increase) while there was little evidence for an association with sleep duration and insomnia risk. Using 341 single nucl...Continue Reading

Related Concepts

Malignant Neoplasm of Breast
Estrogen Receptors
Sleep
Woman
Participant
Single Nucleotide Polymorphism
Adverse Effects
Analysis
Integrated Molecular Analysis of Genomes and Their Expression Consortium
Prospective Cohort Study

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.