Investigating causality in the association between vitamin D status and self-reported tiredness.

Scientific Reports
Alexandra HavdahlGeorge Davey Smith

Abstract

Self-reported tiredness or low energy, often referred to as fatigue, has been linked to low levels of circulating 25-hydroxyvitamin D (25OHD), a biomarker of vitamin D status. Although it is uncertain if the association is causal, fatigue is a common indication for testing, and correcting, low 25OHD-levels. We used two-sample Mendelian randomization to test for genetic evidence of a causal association between low 25OHD-levels and fatigue. Genetic-25OHD associations were estimated from the largest genome-wide association study of vitamin D to date, and genetic-fatigue associations were estimated in 327,478 individuals of European descent in UK Biobank, of whom 19,526 (5.96%) reported fatigue (tiredness or low energy nearly every day over the past two weeks). Using seven genome-wide significant 25OHD-reducing genetic variants, there was little evidence for a causal effect of 25OHD on fatigue (odds ratio for fatigue was 1.05 with 95% confidence interval of 0.87-1.27 per 1-SD decrease in log-transformed 25OHD). There was also little evidence of association between any individual 25OHD-reducing variant and fatigue. Our results suggest that a clinically relevant protective effect of 25OHD-levels on fatigue is unlikely. Therefore, vit...Continue Reading

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Citations

May 5, 2020·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·G H BernhardC C White
Feb 9, 2020·BMJ Open·Lars Petter Jelsness-JørgensenAnne Julsrud Haugen
May 14, 2020·Current Opinion in Gastroenterology·Taha Qazi
Apr 11, 2020·Journal of the International Society of Sports Nutrition·Aleksandra ŻebrowskaBeat Knechtle
Nov 17, 2020·The American Journal of the Medical Sciences·Ilias C PapanikolaouKonstantinos Pagratis

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