Investigating dehydration from compacts using terahertz pulsed, Raman, and near-infrared spectroscopy

Applied Spectroscopy
Karin KogermannClare J Strachan

Abstract

The purpose of this study was to investigate the dehydration of piroxicam monohydrate (PRXMH) in compacts using terahertz pulsed spectroscopy (TPS), Raman spectroscopy, and reflectance near-infrared (NIR) spectroscopy. Compacts were prepared by using PRXMH and poly(tetrafluoro)ethylene powders and combining them in three different manners before compression to produce compacts in which the PRXMH was dispersed throughout the compact, deposited on one face of the compact, or included as a layer within the compact. TPS was a suitable technique to assess the effect of sample preparation on dehydration, whereas Raman and NIR spectroscopy were limited by their sampling depth and the interference of the polymer matrix. TPS revealed that the dehydration behavior depended largely on the compact preparation method. Non-isothermal dehydration was investigated with all three spectroscopic techniques, combined with principal component analysis (PCA) on samples where the PRXMH was deposited on one face of the compact. In addition, variable temperature X-ray powder diffractometry (VT-XRPD) was used to verify the transformation from PRXMH to anhydrous PRX form I, while thermogravimetric analysis (TGA) was used to monitor the water loss. All th...Continue Reading

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Citations

Mar 13, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Margot FonteyneThomas De Beer
Nov 26, 2009·AAPS PharmSciTech·Paroma ChakravartyRaj Suryanarayanan
Jul 13, 2013·Journal of Pharmaceutical and Biomedical Analysis·Renu Chadha, Swati Bhandari
Mar 21, 2008·Journal of Pharmaceutical Sciences·Karin KogermannJukka Rantanen
Aug 12, 2009·Journal of Pharmaceutical Sciences·Anna Cecilia JørgensenJukka Rantanen
Mar 22, 2012·International Journal of Pharmaceutics·Kaisa NaelapääKarin Kogermann
May 18, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Karin KogermannKaisa Naelapää
Jan 18, 2011·Journal of Pharmaceutical and Biomedical Analysis·Norman ChiengJaakko Aaltonen
Sep 3, 2013·International Journal of Pharmaceutics·Andres LustKarin Kogermann
Jan 1, 2015·International Journal of Pharmaceutics·Urve PaaverKarin Kogermann
Nov 23, 2017·Drug Development and Industrial Pharmacy·Mansi UpadhyayBrahmeshwar Mishra

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