Investigating Dependencies of Relative Biological Effectiveness for Proton Therapy in Cancer Cells

International Journal of Particle Therapy
Michelle HowardMichael G Herman

Abstract

Relative biological effectiveness (RBE) accounts for the differences in biological effect from different radiation types. The RBE for proton therapy remains uncertain, as it has been shown to vary from the clinically used value of 1.1. In this work we investigated the RBE of protons and correlated the biological differences with the underlying physical quantities. Three cell lines were irradiated (CHO, Chinese hamster ovary; A549, human lung adenocarcinoma; and T98, human glioma) and assessed for cell survival by using clonogenic assay. Cells were irradiated with 71- and 160-MeV protons at depths along the Bragg curve and 6-MV photons to various doses. The dose-averaged lineal energy ( y ‒ D ) was measured under similar conditions as the cells by using a microdosimeter. Dose-averaged linear energy transfer (LETd) was also calculated by using Monte Carlo (MC) simulations. Survival data were fit by using the linear quadratic model. The RBE values were calculated by comparing the physical dose (D6MV/Dp) that results in 50% (RBE0.5) and 10% (RBE0.1) cell survival, and survival after 2 Gy (RBE2Gy). Proton RBE values ranged from 0.89 to 2.40. The RBE for all 3 cell lines increased with decreasing proton energy and was higher ...Continue Reading

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Citations

Jul 30, 2019·Physics in Medicine and Biology·Eivind RørvikKristian S Ytre-Hauge
Aug 23, 2019·The British Journal of Radiology·Thomas Friedrich
Jun 27, 2019·Journal of Applied Clinical Medical Physics·Koki UenoKikuo Umegaki
Sep 11, 2020·International Journal of Radiation Biology·Ivan M PetrovićGiacomo Cuttone
Dec 3, 2020·Micromachines·Consuelo GuardiolaFaustino Gómez
Aug 8, 2020·International Journal of Radiation Oncology, Biology, Physics·Jeffrey P GrossTeresa K Woodruff
Dec 5, 2020·International Journal of Particle Therapy·Michelle E HowardChris J Beltran
Apr 30, 2021·Journal of Radiation Research·Thomas FriedrichMichael Scholz
Apr 25, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Fredrik KalholmNiels Bassler
Aug 19, 2021·International Journal of Radiation Oncology, Biology, Physics·Harald Paganetti
Oct 29, 2021·International Journal of Radiation Oncology, Biology, Physics·Hans LiewAndrea Mairani

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