Investigating distinct and common abnormalities of resting-state functional connectivity in depression, anxiety, and their comorbid states

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
J Nienke PannekoekNic J A van der Wee

Abstract

Depression and anxiety disorders are highly comorbid and share neurobiological characteristics. However, this is usually not explicitly addressed in studies on intrinsic brain functioning in these disorders. Contrary to previous resting-state reports on small, monodiagnostic subsets of the current sample, we investigated resting-state functional connectivity (RSFC) in medication-free patients with depression, anxiety, comorbid depression and anxiety, and a healthy control group. RSFC was investigated in 140 medication-free subjects: 37 major depressive disorder patients (MDD), 30 patients with one or more anxiety disorders (ANX), 25 patients with MDD and one or more anxiety disorders (COM), and 48 healthy controls (HC). RSFC networks were calculated using a probabilistic independent component analysis. Using a dual regression approach, individuals׳ timecourses were extracted and regressed to obtain subjects-specific spatial maps, which were used for group comparisons in four networks of interest (limbic, default mode, salience and sensory-motor networks). When compared to HC, the COM group showed increased RSFC of the limbic network with a cluster containing the bilateral precuneus, intracalcarine cortex, lingual gyrus, and pos...Continue Reading

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Citations

Feb 17, 2018·ELife·Janine Diane BijsterboschStephen M Smith
May 13, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rebecca B PriceGreg J Siegle
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May 3, 2018·The International Journal of Neuropsychopharmacology·Shabah Mohammad ShadliPaul Glue
Jan 30, 2021·Cerebral Cortex·Zhihao WangPengfei Xu
Feb 16, 2021·Journal of Affective Disorders·Wendela G Ter MeulenBrenda W J H Penninx
Jul 24, 2021·Journal of Affective Disorders·Julian PackheiserSebastian Ocklenburg
Aug 14, 2021·Journal of Psychiatric Research·Lisa SindermannElisabeth Johanna Leehr
Aug 15, 2021·NeuroImage·Jiahe ZhangSusan Whitfield-Gabrieli

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