Investigating epidemiologic trends and the geographic distribution of patients with anal squamous cell carcinoma throughout Canada.

Current Oncology
Leila CattelanIvan V Litvinov

Abstract

Anal cancer is a rare disease, constituting 0.5% of new cancer cases in the United States. The most common subtype is squamous cell carcinoma (scc). Studies in several developed nations have reported on an increasing incidence of anal cancer in recent decades, and various risk factors pertaining to the pathogenesis of the disease have been identified, including infection with the human papillomavirus, tobacco use, and immunosuppression. The epidemiology and distribution of anal scc throughout Canada remain poorly understood, however. Using 3 population-based cancer registries, a retrospective analysis of demographic data across Canada for 1992-2010 was performed. The incidence and mortality for anal scc was examined at the levels of provinces, cities, and the forward sortation area (FSA) component (first 3 characters) of postal codes. During 1992-2010, 3720 individuals were diagnosed with anal scc in Canada; 64% were women. The overall national incidence rate was 6.3 cases per million population per year, with an average age at diagnosis of 60.4 years. The incidence increased over time, with significantly higher incidence rates documented in British Columbia and Nova Scotia (9.3 cases per million population each). Closer examin...Continue Reading

Citations

Feb 23, 2021·Current Oncology·François LagacéIvan V Litvinov
Apr 18, 2021·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Yasi XiaoIvan V Litvinov

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